J Neurosci Methods 2007; 160: 215–22 17 Shafer SL, Hendrickx JF, Flood P, Sonner J, Eger EI II. Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms. Anesth Analg 2008; 107: 507–24 18 Kuhlmann L, Foster BL, Liley DT. Modulation of functional EEG networks by the NMDA antagonist nitrous oxide. PLoS One 2013; 8: e56434 19 Barr G, Jakobsson JG, Owall A, Anders...

Editor’s key points † The influence of electromyographic (EMG) activity neuromuscular block (NMB) on bispectral index (BIS) is controversial. † BIS was measured before and after reversal of NMB with sugammadex or neostigmine. † BIS increased after both agents only in patients with EMG activity. † This effect should be taken into account when using BIS. Background. Sugammadex is a modified g-cyc...

BACKGROUND Postoperative mortality has been associated with cumulative anesthetic duration below an arbitrary processed electroencephalographic threshold (bispectral index [BIS] <45). This substudy of the B-Unaware Trial tested whether cumulative duration of BIS values lower than 45, cumulative anesthetic dose, comorbidities, or intraoperative events were independently associated with postopera...

Introduction: Ensuring an adequate Depth of Anesthesia (DOA) during surgery is essential for anesthesiologists. Since the effect of anesthetic drugs is on the central nervous system, brain signals such as Electroencephalogram (EEG) can be used for DOA estimation. Anesthesia can interfere among brain regions, so the relationship among different areas can be a key factor in the anesthetic process...

Background &amp; objectiveː Anesthetic management of pediatric cataract surgery is special as most these surgeries have to be completed under general anesthesia, and airway adequate ventilation take precedence care. We compared spontaneous vs. controlled ventilation, using laryngeal mask (LMA) with or without muscle relaxation showing their impact on different parameters in surgery.&#x0D; Metho...

We have compared the auditory evoked potential index (AEPIndex) and bispectral index (BIS) for monitoring depth of anaesthesia in spontaneously breathing surgical patients. Twenty patients (aged 17-49 yr) undergoing day surgery were anaesthetized with computer-controlled infusions of propofol. The mean (SD and range) of each measurement was determined during consciousness and unconsciousness an...