background: bladder cancer is one of the most common cancers in the world with considerably higher frequency among men than women. treatment of the disease is possible according to early diagnosis, so identifying useful markers is very important. lsinct5 (long stress-induced non-coding transcript 5) is a stress-regulated lncrna involved in response to oxidative stress, also in cell proliferatio...

background: breast cancer is the most common diagnosed cancer among women in the world. snail1 plays a role in the development of the invasive phenotypes of cancer, neural cell differentiation, cell division and apoptosis in tumor cells. traces of snail1 in metastasis of breast cancer to bone are observed. the aim of this study was to investigate the effect of specific snail1 sirnas on the prol...

mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

Introduction: Bladder cancer is regarded as the most common urinary malignancy in the world. As other cancers, its incidence has increased in recent years. Hence, the present study was conducted to investigate the relationship between smoking and opium and bladder cancer in residents of Yazd province. Materials and Methods: This case-control study was performed on 200 patients with ...

PAX8 is a transcription factor with a role in ontogenesis of the urinary tract. The aim of the present investigation was to investigate PAX8 expression in normal bladder and in non-invasive urothelial tumours. Nine cases of normal urothelial mucosa, 2 cases of papillary urothelial neoplasia of low malignant potential, 12 cases of low grade non-invasive papillary urothelial carcinoma and 16 case...

Objective (s): This study aimed at investigation of preparation and stability study of Mitomycin and Mitomycin loaded nanoliposems and efficacy of the combination of Mitomycin -loaded nanoliposomes and Curcumin versus Mitomycin in suppressing HTB-9 and L929 cell lines, in vitro.Materials and Methods: An HPLC method was validated based on Q2 (R1) International Conference on Harmonization (ICH) g...

background- cd24 is a cell adhesion molecule that has been implicated in metastatic tumor progression cells. our aim was clarify correlation between cd24 expression and camp:cgmp ratio in murine colorectal cancer cell line (ct26) after using cholera toxin. materials and methods- the ct26 cells were cultured in microtubes for assaying camp and cgmp; also the cells were cultured in flasks for ass...

results there was no statistical difference between the 2 groups with respect to the recurrence rate (p > 0.05). although the recurrence interval was longer for the metformin group, this increase was not statistical significant (p > 0.05). furthermore, tumor recurrence had no correlation with sex or the grade of the tumors. conclusions according to our findings, it seems that metformin has no c...

Resistance to conventional anticancer chemotherapeutic agents remains one of the major problems in the treatment of bladder cancer. Hence, new therapeutic modalities are necessary to treat the drug-resistant cancers. Apo-2 ligand (Apo-2L) is member of the tumor necrosis factor ligand family, and it induces apoptosis in cancer cells. Several cytotoxic anticancer drugs, including Adriamycin (ADR)...