Reza Kazemi Oskuee
Neurogenic Inflammation Research Center, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease
Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate Kupffer cells. Curcumin is an active ingredient of the rhizome of turmeric. The...
[ 2 ] - A simple, sensitive and rapid isocratic reversed-phase high-performance liquid chromatography method for determination and stability study of curcumin in pharmaceutical samples
Objective: This study was designed to develop and validate a new reversed-phase high-performance liquid chromatography (RP-HPLC) method based on Q2 (R1) International Conference on Harmonization (ICH) guideline for determination of curcumin in pharmaceutical samples. Materials and Methods: The HPLC instrument method was optimized with isocratic elution with acetonitrile: ammonium acetate (45:55...
[ 3 ] - The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial
Objective: Diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. Curcumin inhibits NF-κB signaling pathway. The aim of this study is evaluation of the effect of Nano-curcumin on HbA1C, fast blood glucose and lipid profile in diabetic patients. Materials and Methods:...
[ 4 ] - Novel delivery system for natural products: Nano-curcumin formulations
Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmaco...
[ 5 ] - تهیه و ارزیابی نانوحامل های پلیمری حاصل از اتصال پلی اتیلن ایمین به پلی ال لیزین با استفاده از لینکر 10 کربنه به منظور انتقال ژن به سلول یوکاریوتی
Background & Aim: A lack of efficient gene-delivery carriers has always been the biggest challenge in gene therapy. Polyethylenimine (PEI) and poly (L-lysine) (PLL) are the most studied non-viral gene carriers. The purpose of this study is to prepare new nano-carriers, by conjugating these two polymers via 10 carbon linkers (10-bromodecanoic acid), in order to take advantage of them and compens...
[ 6 ] - انتقال siRNA به سرطان ریه با استفاده از نانوذرات
سرطان ریه شایع ترین علت مرگ و میر ناشی از سرطان در جهان می باشد و سالانه بیشتر از یک میلیون نفر به علت ابتلا به این بیماری جان خود را از دست می دهند. این سرطان به دو گروه اصلی به نام های سرطان ریه با سلول های غیر کوچک (NSCLC) و سرطان ریه با سلول های کوچک (SCLC) تقسیم می شود این دو گروه در خصوصیات بسیاری از جمله رفتارهای بیولوژیک، پاسخ به درمان و تغییرات ژنتیکی متفاوت هستند. مقاومت به درمانهای م...
[ 7 ] - Curcumin improved liposomal mitomycin-induced cell toxicity in bladder cancer cell
Objective (s): This study aimed at investigation of preparation and stability study of Mitomycin and Mitomycin loaded nanoliposems and efficacy of the combination of Mitomycin -loaded nanoliposomes and Curcumin versus Mitomycin in suppressing HTB-9 and L929 cell lines, in vitro.Materials and Methods: An HPLC method was validated based on Q2 (R1) International Conference on Harmonization (ICH) g...
[ 8 ] - Evaluation of leishmanicidal effect of Euphorbia petiolata extract by in vivo anti-leishmanial assay using promastigotes of Leishmania major
Objective: The extract of different species of Euphorbia has been successfully used as a remedy for treatment of cutaneous leishmaniasis. The aim of this study was to assess the in vitro leishmanicidal effect of Euphorbia petiolata (E. petiolata) extract. Materials and Methods: Ethanolic percolated and methanolic Soxhlet extract of E. petiolata on promastigotes of L. major at different concentr...
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