نتایج جستجو برای: bundling
تعداد نتایج: 2852 فیلتر نتایج به سال:
In this paper, we consider the design of an agent that is able to autonomously make optimal bundling decisions when selling multiple heterogeneous items within existing online auctions. We show that while bundling the items together into a single lot is effective at reducing listing costs, it also results in a loss in auction revenue. To address this loss we introduce a novel bundling strategy,...
BACKGROUND Bundling, which consists of wrapping an infant for prolonged periods in a sheepskin cover after dried cow dung is applied, is a common and apparently unique practice limited to the rural, mountainous regions of Northern Pakistan. The practice is initiated at various ages during the neonatal period. Its potential contribution to neonatal tetanus (NNT) had not been evaluated. METHODS...
L-plastin is a calcium-regulated actin-bundling protein that is expressed in cells of hematopoietic origin and in most metastatic cancer cells. These cell types are mobile and require the constant remodeling of their actin cytoskeleton, where L-plastin bundles filamentous actin. The calcium-dependent regulation of the actin-bundling activity of L-plastin is not well understood. We have used NMR...
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone
Midzone microtubules of mammalian cells play an essential role in the induction of cell cleavage, serving as a platform for a number of proteins that play a part in cytokinesis. We demonstrate that PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage, is a microtubule binding and bundling protein both in vivo and in vitro. Overexpression of PRC1 extensively bundle...
The espins are actin-binding and -bundling proteins localized to parallel actin bundles. The 837-amino-acid "espin" of Sertoli cell-spermatid junctions (ectoplasmic specializations) and the 253-amino-acid "small espin" of brush border microvilli are splice isoforms that share a C-terminal 116-amino-acid actin-bundling module but contain different N termini. To investigate the roles of espin and...
Actin capping and cross-linking proteins regulate the dynamics and architectures of different cellular protrusions. Eps8 is the founding member of a unique family of capping proteins capable of side-binding and bundling actin filaments. However, the structural basis through which Eps8 exerts these functions remains elusive. Here, we combined biochemical, molecular, and genetic approaches with e...
This paper presents a graph bundling algorithm that agglomerates edges taking into account both spatial proximity as well as user-defined criteria in order to reveal patterns that were not perceivable with previous bundling techniques. Each edge belongs to a group that may either be an input of the problem or found by clustering one or more edge properties such as origin, destination, orientati...
Strigolactones (SLs) are plant hormones that regulate the plant response to phosphate (Pi) growth conditions. At least part of SL-signalling execution in roots involves MAX2-dependent effects on PIN2 polar localization in the plasma membrane (PM) and actin bundling and dynamics. We examined PIN2 expression, PIN2 PM localization, endosome trafficking, and actin bundling under low-Pi conditions: ...
We develop a theory of agenda-setting in a legislature. A proposer supports a platform comprised of several policies. Policies are divisible and can be bundled — the proposer can slice each policy into parts, and she can aggregate the various policy parts into bills. The proposer chooses an agenda, which is a collection of bills. The legislature votes each bill up or down, and all the policy pa...
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