BACKGROUND NICE guidance on the investigation and treatment of ovarian cancer advocates that the tumour marker CA125 should be the first line investigation for women suspected of having ovarian cancer. METHODS An internet-based survey, of primary care doctors in the West Midlands, was conducted in order to ascertain the views of general practitioners (GPs) of NICE guidance on the use of CA125...

Purpose: Biomarkers for the early detection of pancreatic cancer are urgently needed. The primary objective of this study was to evaluatewhether increased levels of serumCA19-9, CA125, CEACAM1, and REG3A are present before clinical presentation of pancreatic cancer and to assess the performance of combined markers for early detection and prognosis. Experimental Design: This nested case–control ...

PURPOSE Efforts to validate ovarian cancer early detection biomarkers with immunoassays are challenged by the limited specimen volumes available. We sought to develop a specimen-efficient assay to measure CA125 in serum, assess its reproducibility, validity, and performance, and test its potential for multiplexing and combining with human epididymis protein 4 (HE4), a promising novel ovarian ca...

Of all of the epithelial ovarian cancers (EOC), clear cell adenocarcinoma (CCA) has the worst clinical prognosis. Furthermore, the conventional EOC biomarker CA125 is more often negative in CCA than in other subtypes of EOC. This study sought to discover a new diagnostic biomarker that would allow more reliable detection of CCA. Using mass spectrometry, we compared proteins in conditioned media...

Abstract Background: CA125 levels in Meig’s syndrome can increase or be normal which an unusual laboratory condition is. In this paper, we present a case of Meigs’ syndrome associated with increased CA125 level due to ovarian fibroma / thecoma. Case presentation: A 50-year old Iranian woman presented with fever, abdominal pain and distention and in imaging assessment, a 90×109 mm heterogeneou...

background: peritoneal tuberculosis accounts 1-2% of all forms of tuberculosis. peritoneal tuberculosis is an important differential diagnosis for ovarian cancer in women with ascites, adnexal mass and elevated cancer antigen 125 (ca125) levels. we report a case of a 32- year -old woman with multiple miliary peritoneal deposits mimicking advanced ovarian carcinoma. case presentation: a 32-year-...

Purpose: To investigate the diagnostic value of CA 19.9 & CA125 in patients cancer. Methods: 100 randomly selected coming to Medicine Gynae OPD with symptoms Serum was taken and CA19.9 125 analyzed by Electrochemiluminescent Immunoassay. Results: It showed serum levels patient malignant ovarian, endometriosis pancreatic tumor significantly higher than control group. Out total 50 for CA19.9,...

PURPOSE CA 125 was evaluated in the sera of patients with aggressive NHL, together with LDH and β2m, in a trial to assess its value in the diagnosis and follow-up, and to compare it to some prognostic factors. SUBJECTS AND METHODS The study included 78 newly diagnosed patients with diffuse large B cell non-Hodgkin's lymphoma (DLBCL), with age range 18-60 years, and a WHO performance status of...