Gastric cancer is common in China, and its early diagnosis and treatment are difficult. In recent years great progress has been achieved in gene therapy, and a wide array of gene therapy systems for gastric cancer has been investigated. The present article deals with the general principles of gene therapy and then focuses on how these principles may be applied to gastric cancer.

Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral ...

background: colorectal cancer (crc) is a common and lethal malignancy worldwide. the incident rate of crc is different in various geographica regions. crc is a multifactorial disease; the factors involved included dietary and genetic factors. p53 gene is the most important tumor suppressor gene which involved in many cancers. the mutation rate in exons 7 and 8 of p53 gene in crc was reported to...

abstract objective : this study is conducted to compare meta-cognition treatment and mindfulness-based stress reduction treatment on life quality of women with breast cancer. method: in aquasi-experimental design, with pre-test and post-test and controlgroup,36 patients with a diagnosis of breast cancer, among patients who referred to the division of oncology and radiotherapy of imam hossein  h...

background: cancer is a major source of distress such as aggression and anxiety. it becomes a traumatic and painful for both children and their family.  therefore, the aim of this study was to investigate the influence of painting therapy on the reduction of aggression and anxiety among hospitalized children with cancer (8-12 aged). methods: the study was semi-experimental with pretest-posttest...

conclusions: according to finding of this study, in accordance to most of other researches, ginger is an effective agent to reduce chemotherapy-induced nausea and vomiting. however, there are some researches supporting ginger as a moderate antiemetic agent among cancerous patients under chemotherapy. results: findings of the study indicated that subjects receiving ginger showed significant redu...

Background and Objective:Determination of HER2 gene is crucial in breast carcinoma management and prognosis, as HER2 alterations are linked to a shorter disease-free period, overall survival and resistance to tamoxifen anti-estrogen therapy and other chemotherapy regimens, regardless of the nodal or hormone receptor status. This study aimed to...

Gastric cancer is one of the most common cancers in the world. Late diagnosis is the main cause of the high rate of treatment failure and death among patients with gastric cancer; therefore identifying the molecular basis of cancer initiation and metastasis is so critical for developing efficient methods for early diagnosis and therapy. long non-coding RNAs (lncRNAs) are the largest group of no...

Proper and timely segregation of the cellular genome is a prime requirement all cell division programs. Mis-segregation chromosomes resulting aneuploidy lead to several clinical consequences. Over years, shugoshin has emerged as key protein factor involved in genetic material dividing cells. Deletion or an altered level reported human malignancies; result, now emerging important tumor-associate...