Åkerbladh, L. 2017. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions. Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 237. 86 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0083-2. Palladium-catalysed carbonylative multicomponent reaction...

The mitochondrial respiratory chain is required for the induction of some yeast hypoxic nuclear genes. Because the respiratory chain produces reactive oxygen species (ROS), which can mediate intracellular signal cascades, we addressed the possibility that ROS are involved in hypoxic gene induction. Recent studies with mammalian cells have produced conflicting results concerning this question. T...

thermodynamic restrictions and simultaneous effects of operational conditions on the homogeneous rhodium-catalyzed carbonylation of methanol are studied in this line of research. it is shown that the general nrtl-virial model can be appropriated to study thermodynamics of the carbonylation. it is obtained that the reaction is kinetically and thermodynamically reasonable at temperatures above 42...

A novel palladium-catalyzed oxidative carbonylation reaction was developed via the carbon monoxide insertions between the amine group and the carbonyl group to realize the intramolecular cyclization, which provides efficient access to 1,3,4-oxadiazol-2(3H)-ones with a wide range of substrates under mild conditions, resulting in good to excellent yields.