BACKGROUND AND AIM Oral bisphosphonates have been shown to reduce the risk of fractures in patients with osteoporosis. It can be assumed that the clinical effectiveness of oral bisphosphonates depends on persistence with therapy. METHODS The influence of persistence with and adherence to oral bisphosphonates on fracture risk in a real-life setting was investigated. Data from 4451 patients wit...

underground dams have recently been considered as hydrological structures for the development of water resources, especially in the dry regions of iran. in this investigation along with the basic studies and the aquifer flow modeling, the probable hydrogeological effects of an underground dam are investigated. the proposed place for the ganjeh underground dam is chehel-khaneh aquifer located in...

G2D (genes to diseases) is a web resource for prioritizing genes as candidates for inherited diseases. It uses three algorithms based on different prioritization strategies. The input to the server is the genomic region where the user is looking for the disease-causing mutation, plus an additional piece of information depending on the algorithm used. This information can either be the disease p...

In the present research, the mixed-mode fracture mechanics analysis in a plate with central hole under tensile loading is considered. It is assumed that a plate containing two symmetrical hole-edge cracks is bonded with two dissimilar planes. The stress intensity factors at the crack tips are calculated. The problem is modeled in Casca software and this model is analyzed with Franc software. Th...

Somatic mutations must happen often during development because of the large number of cell divisions to expand from a single-cell zygote to a full organism. A mutation in development carries forward to all descendant cells, causing genetic mosaicism. Widespread genetic mosaicism may influence diseases that derive from a few genetically altered cells, such as cancer. I show how to predict the ex...