Subchronic toxicity of carbon tetrachloride (CCl4) was examined by inhalation exposure of F344 rats and BDF1 mice of both sexes to 0, 10, 30, 90, 270 or 810 ppm (v/v) CCl4 vapor for 13 wk (6 h/d and 5 d/wk). In the high exposure levels at 270 and 810 ppm, altered cell foci in the livers of both rats and mice, and fibrosis and cirrhosis in the rat liver were observed. Hematoxylin and eosin-stain...

Justicia adhatoda (vasaka) leaves have long been used in Indian Ayurvedic system of medicine as antitussive. Its crude extract has been previously reported to have hepatoprotective activity. Vasicinone was isolated from leaves of J. adhatoda, column purified and characterized using, TLC UV, FT-IR and 1H NMR. The isolated vasicinone was evaluated for hepatoprotective activity using (CCl4)-induce...

--------------------------------------------------------------ABSTRACT------------------------------------------------------Studies have shown that certain parts of Moringa oleifera Lam plant, such as its leaves, roots, flowers, and seeds possess antihepatotoxic activity. Also in recent times, there has been a surge in local demand for Moringa seed oil, largely due to its reportedly high medici...

Background: Carbon tetrachloride (CCl4) is a critical hepatotoxicant causing liver injury and fibrosis via hepatic production of reactive oxygen species (ROS). Apigenin (APG) natural bioactive compound flavonoid antioxidant. We, therefore, evaluated whether APG could mitigate CCl4-mediated hepatotoxicity. Methods: Rats were randomly divided administered and/or CCl4 in Control group, + groups (A...

The methanolic extract and fractions (ethyl acetate and butanol) of Senna alata, a major medicinal plant used in traditional medicine in Nigeria were evaluated for possible hepatoprotective activity against carbon tetrachloride (CCl4) – induced hepatotoxicity in wistar albino rats. Phytochemical screening indicates the presence of tannins, phlobatannins, alkaloids, anthraquinones, flavonoids, c...

The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the methanol extract of Eupatorium ayapana (MEEA) (Family- Asteraceae) leaves in Wistar albino rats. The different groups of animals were administered with carbon tetrachloride (CCl4) at 72 h interval.  The MEEA at 100, 200 and 300 mg/kg and silymarin 25 mg/kg were administered to the CCl4 treated ...

ABSTRACT Hepatotoxicity is the most common disorder with severe effects on quality of life. Tragopogon graminifolius DC. has been used in Iran as an astringent and bleeding inhibitor, wound healer and gastro-protector agent. To our knowledge, there are little evidence at hand on hepatoprotective activity of T. graminifolius. The present study was carried out to assess hepatoprotective propert...

Nanoparticles are important scientific tools that have been recruited in various biotechnological, pharmacological applications. Zinc oxide nanoparticles are used considerably for its catalytic, electrical, optoelectronic and photochemical properties. Quininecontaining anthracycline antibiotic doxorubicin (DXR) has been used for the treatment of a wide variety of cancers, despite of its high an...