A community was exposed for several days to formaldehyde (HCHO), hexamethylenetetramine, trimethylamine, and paraformaldehyde emitted from an overheated tanker car containing ureaformaldehyde resin. Residents experienced acute HCHO symptoms at the time of the accident. Many developed chronic, multiple organ health complaints. Three years following the accident, exposed subjects were compared to...

In their interesting study on the concomitant reduction in inflammatory and oxidative stress and mean amplitude of glycemic excursions (MAGE) following treatment with dipeptidyl peptidase-IV (DPP-4) inhibitors, sitagliptin and vildagliptin, in patients with type 2 diabetes, Rizzo et al. (1) propose that the reduction in MAGE leads to the reduction in indices of oxidative and inflammatory stress...

UNLABELLED The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe respiratory infection with a high mortality rate (~35%). MERS-CoV has been a global threat due to continuous outbreaks in the Arabian peninsula and international spread by infected travelers since 2012. From May to July 2015, a large outbreak initiated by an infected traveler from the Arabian p...

b-thalassemia là một bệnh rối loạn di truyền lặn do đột biến gen HBB nằm trên cánh ngắn nhiễm sắc thể số 11 gây suy giảm tổng hợp chuỗi b-globin. Mỗi năm có khoảng 60.000 – 70.000 trẻ em sinh ra bị toàn thế giới trong đó Việt Nam. Trên 350 đã được công bố. Phát hiện người lành mang vai trò quan trọng tư vấn truyền, chẩn đoán trước và tiền làm tổ nhằm tỉ lệ bệnh. Nghiên cứu thực với mục tiêu “xá...

Innate lymphoid cells (ILC) are key players in tissue homeostasis and the regulation of local immunity barrier organs such as skin. The functional properties ILC reflected by their protein expression, proteins being end-stage products active genes. To characterize proteome human skin ILC, we performed in-depth proteomic analyses (mass spectrometry-based) on ILC2 ILC3 purified from healthy (N=10...

Due to their ability to inhibit antigen-induced T-cell activation in vitro and in vivo, anergic T cells can be considered part of the spectrum of immunoregulatory T lymphocytes. Here we report that both murine and human anergic T cells can impair the ability of parenchymal cells (including endothelial and epithelial cells) to establish cell-cell interactions necessary to sustain leukocyte migra...

Wnt/β-catenin activation in adult epidermis can induce new hair follicle formation and tumor development. We used lineage tracing to uncover the relative contribution of different stem cell populations. LGR6(+) and LRIG1(+) stem cells contributed to ectopic hair follicles formed in the sebaceous gland upon β-catenin activation, whereas LGR5(+) cells did not. Lgr6, but not Lrig1 or Lgr5, was exp...