Background & Aims: Acute lymphoblastic leukemia (ALL) is the most common malignancies in the world. Despite advances in treatment of patients with ALL, a subset of patients will have recurrent disease or refractory to chemotherapy and hematopoietic stem cell transplant. Consequently, assessment of the effectiveness of natural compounds with high efficacy and minimal side effects is warranted. I...

The aim of our work was to compare cytotoxic and membrane-damaging effects of O. majorana L. essential oil and linalool on Hep G2 and to investigate their possible protective (antioxidant) effects against H2O2 induced membrane damage. The oils were investigated by GC and GC-MS and antioxidant activity was evaluated by DPPH and -carotene–linoleic acid assays. Assessment of cell viability was ma...

Introduction: Mesenchymal Stem Cells (MSCs) are multipotent cells capable of duplication and auto-recovery and distinction from various cells including chondrocytes, adipocytes, chondroblasts, fibroblasts, and osteoblasts. Human stem cells are always subject to local and external mechanical loads. External loads are caused by physical activity in external environment loading to infliction of st...

Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...

background: oligodendrocytes, the myelinating glial cells of central nervous system, are highly vulnerable to ischemic‑induced excitotoxic insult, a phenomenon in which calcium overload triggers cell death. berberine is an alkaloid extracted from medicinal herbs as coptidis rhizoma with several pharmacological effects like inhibition of neuronal apoptosis in cerebral ischemia. methods: we exami...

This study aimed to examine the differences in the morphological properties and proliferation of olfactory ensheathing cells in three-dimensional culture on collagen-heparan sulfate biological scaffolds and in two-dimensional culture on common flat culture plates. The proliferation rate of olfactory ensheathing cells in three-dimensional culture was higher than that in two-dimensional culture, ...

Myo-inositol (MI) which is produced at low concentration is an essential substance for animal’s natural growth. This study was performed to investigate the effects of MI on viability, proliferation and some biochemical factors of rat bone marrow mesenchymal stem cells (BMSCs). To investigate the cell viability using trypan blue assay, BMSCs after third passage were treated with different concen...