سید هادی موسوی
دانشیار گروه فارماکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
[ 1 ] - بررسی اثر عصاره هیدروالکلی کلم قرمز بر مهار رشد و القاء آپوپتوز در سلول های سرطانی پستان (MCF-7)
مقدمه: سبزیجات براسیکا متعلق به خانواده کلم بوده و شامل انواع مختلف کلم (قرمز، سبز و ...)، گل کلم، کلم بروکلی و کلم پیچ می باشد. گزارشات نشان می دهند که مصرف این گیاهان در کاهش خطر ابتلاء به بیماری های حاد مانند بیماری قلبی عروقی و سرطان مؤثرند. یک گروه از این خانواده کلم قرمز می باشد. مطالعات نشان داده اند که کلم قرمز حاوی ترکیباتی است که در درمان بیماری های مختلف از جمله سرطان نقش دارند. مطال...
[ 2 ] - Synergistic effects of Ferula gummosa and radiotherapy on induction of cytotoxicity in HeLa cell line
Objective: Cervical cancer is the second most common type of cancer among women, worldwide; and for treatment of this type of cancer radiotherapy is commonly used. Ferula gummosa Boiss(“Barije” in Persian, from the family Apiaceae), (F. gummosa), is an extremely precious medicinal plant which naturally grows throughout the Mediterranean and Central Asia and is a native plant in Iran. The presen...
[ 3 ] - Kelussia odoratissima potentiates cytotoxic effects of radiation in HeLa cancer cell line
Objective: Cervical cancer is the second most common cause of death from cancer in women throughout the world. The aim of this study was to evaluate the cytotoxic activity of Kelussia odoratissima (K. odoratissima) extract associated with radiotherapy in cervical cancer cells (HeLa cell line).Materials and Methods: Different concentration of the extract (25-500µg/ml) was tested in HeLa cell lin...
[ 4 ] - Cytotoxic and apoptogenic effects of Bryonia aspera root extract against Hela and HN-5 cancer cell lines
Objective: Bryonia aspera (Stev. ex Ledeb) is a plant that grows in northeast of Iran. In the present study, cytotoxic and apoptogenic properties of B. aspera root extract was determined against HN-5(head and neck squamous cell carcinoma) and Hela (cervix adenocarcinoma) cell lines. Materials and Methods: HN-5 and Hela cell lines were cultured in DMEM medium and incubated with different concent...
[ 5 ] - Ctotoxic and apoptogenic effects of Perovskia abrotanoides flower extract on MCF-7 and HeLa cell lines
Objective: Perovskia abrotanoides Karel, belongs to the family Lamiaceae and grows wild alongside the mountainous roads inarid and cold climate of Northern Iran. The anti-tumor activity of P. abrotanoides root extract has been shown previously. This study was designed to examine in vitro anti-proliferative and pro-apoptotic effects of flower extract of P. abrotanoides on MCF-7 and Hela cell lin...
[ 6 ] - Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species
Objective: Oxidative stress plays a key role in the pathophysiology of brain ischemia and neurodegenerative disorders.Previous studies indicated that Viola tricolor and Viola odorataare rich sources of antioxidants. This study aimed to determine whether these plants protect neurons against serum/glucose deprivation (SGD)-induced cell death in an in vitro model of ischemia and neurodegeneration....
[ 7 ] - Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line
Objectives: 7-prenyloxycoumarins are a group of secondary metabolites that are found mainly in plants belonging to the Rutaceae and Umbelliferae families. This study was designed to evaluate and compare the cytotoxic and apoptotic activity of 7-prenyloxycoumarin compounds and herniarin on MCF-7, a breast carcinoma cell line. Materials and Methods: Cells were cultured in RPMI medium and incubate...
[ 8 ] - Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial
Objective: Cancer represents the second cause of mortality in the world. Saffron as a medicinal plant is known for its anti-cancer and anti-depressant properties. In this randomized double blind clinical trial, the effects of saffron on response to treatment in patients suffering from liver metastasis were evaluated. Materials and Methods: Thirteen patients suffering from liver metastases who r...
[ 9 ] - Study of cytotoxic properties of Rosa damascena extract in human cervix carcinoma cell line
Objective: Cancer is a major health problem worldwide and current therapies for cancer are often limited by short-term efficacy due to drug resistance. There has been much interest in the use of naturally occurring compounds with chemo-preventive and chemotherapeutic properties in the treatment of cancers. Rose is one of the most important groups of ornamental plants which their fruits and flo...
[ 10 ] - In vitro assessment of alendronate toxic and apoptotic effects on human dental pulp stem cells
Objective(s): Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hDPSCs). Materials and Methods: The mesenchymal stem cells (MSCs), obtained ...
[ 11 ] - The evaluation and comparing of cytotoxic effects of Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima and Artemisia kopetdaghensis extracts on ACHN cell line
Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients It is resistant to chemotherapy. Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima and Artemisia kopetdaghensis are herbs that there are some cytotoxic activity reports about them. In this study cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN) were evaluated and compared.ACHN...
[ 12 ] - Study of crocin & radiotherapy-induced cytotoxicity and apoptosis in the head and neck cancer (HN-5) cell line
Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...
[ 13 ] - In vitro evaluation of cytotoxic and apoptogenic properties of Sophora pachycarpa
Sophora pachycarpa Schrenk ex C.A.Mey. belongs to the family Fabaceae. Some species of the genus Sophora have shown to possess anti-proliferative and apoptosis-inducing activites in cancer cells. However, there is no available information addressing this effect in S. pachycarpa. Here, we investigated the cytotoxic effects of methanol extract and different fractions obtained from S. pachycarpa r...
[ 14 ] - Apoptosis Induction of Salvia chorassanica Root Extract on Human Cervical Cancer Cell Line
Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...
[ 15 ] - The evaluation and comparing of cytotoxic effects of Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima and Artemisia kopetdaghensis extracts on ACHN cell line
Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients It is resistant to chemotherapy. Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima and Artemisia kopetdaghensis are herbs that there are some cytotoxic activity reports about them. In this study cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN) were evaluated and compared.ACHN...
[ 16 ] - Study of crocin & radiotherapy-induced cytotoxicity and apoptosis in the head and neck cancer (HN-5) cell line
Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...
[ 17 ] - In vitro evaluation of cytotoxic and apoptogenic properties of Sophora pachycarpa
Sophora pachycarpa Schrenk ex C.A.Mey. belongs to the family Fabaceae. Some species of the genus Sophora have shown to possess anti-proliferative and apoptosis-inducing activites in cancer cells. However, there is no available information addressing this effect in S. pachycarpa. Here, we investigated the cytotoxic effects of methanol extract and different fractions obtained from S. pachycarpa r...
[ 18 ] - Apoptosis Induction of Salvia chorassanica Root Extract on Human Cervical Cancer Cell Line
Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...
[ 19 ] - Neuroprotective effect of Nigella sativa hydro alcoholic extract on serum/glucose deprivation induced PC12 cells death
Introduction: The Serum/Glucose deprivation -induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders. Nigella sativa L. has been known as a source of antioxidants. To elucidate the neuroprotective actions of N. sativa extract in vitro, we studied the effect of N. sativa extract on cultured PC12 cells under s...
[ 20 ] - Study of Cytotoxic Effects of Saffron in MCF-7 Cells
Current therapies for breast cancer are often limited by short-term efficacy due to the emergence of drug resistance. There has been increased interest in the use of naturally occurring compounds with chemopreventive and chemotherapeutic effects in the treatment of cancers. Saffron, dry stigmas Crocus sativus L., used in Iran as a spice, is known for its anticancer properties. In...
[ 21 ] - Cytotoxic effects of auraptene against a human malignant glioblastoma cell line
Objective: Glioblastoma multiforme (GBM) is the deadliest type of primary brain tumors, and the survival of patients is estimated to be only about one year. This study, for the first time, investigated the cytotoxic effects of auraptene on U87 GBM cell line.<b...
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