The chronic fatigue syndrome is a condition receiving increasing recognition. Symptoms of depression are not infrequent and may be persistent and severe enough to warrant treatment. The controversy over the use of antidepressant therapy in this condition may present a dilemma for the general practitioner considering possible treatments. This paper draws on the literature and on the authors' own...

  Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinic...

WHY: Older adults hospitalized for a newly diagnosed acute condition or an exacerbation of a chronic condition are at heightened risk of rehospitalization due to poorly managed transitions from hospital to home or other care setting. For older patients with multiple chronic conditions this “hand-off” period takes on even greater importance. One-quarter to one-third of older adults with multiple...

Leg pain is a common presentation to the outpatient department. Bilateral calf chronic compartment syndrome is a rare cause of bilateral calf pain. Although this condition has been well documented in young athletes, it has rarely been reported in the elderly. We present the case of a 68-year-old male bodybuilder with bilateral calf chronic compartment syndrome, describe the presentation and eva...

Inflammatory bowel disease (IBD) is a chronic, sometimes debilitating condition that affects mainly the young population. The effect of IBD on pregnancy is therefore an important clinical issue. Many Obstetricians are likely to come across the occasional patient with this chronic condition. The following article discusses the salient factors which need to be considered in pregnant women with IB...

A minimal intervention, based on cognitive-behavioural therapy for chronic fatigue syndrome and consisting of self-instructions combined with email contact, was tested in a randomised controlled trial (ISRCTN27293439). A total of 171 patients participated in the trial: 85 were allocated to the intervention condition and 86 to the waiting-list condition. All patients met the Centers for Disease ...

Exfoliative cheilitis is an inflammatory condition that can significantly impair quality of life. This the first reported case interleukin-23 inhibitor, tildrakizumab, for treatment a chronic, refractory exfoliative cheilitis.

Introduction and objectives. Data on chronic anemia following heart transplantation (HT) are scarce and contradictory. Our aims were to determine the prevalence of chronic anemia after HT, to identify predisposing factors for the condition at 12 months, and to evaluate its influence on mediumterm and long-term survival. Methods. Retrospective analysis of patients who underwent HT between 1991 a...

OBJECTIVES To estimate the proportion of children who die with chronic conditions and examine time trends in childhood deaths involving chronic conditions. DESIGN Retrospective population-based death cohort study using linked death certificates and hospital discharge records. SETTING England, Scotland and Wales. PARTICIPANTS All resident children who died aged 1-18 years between 2001 and ...

Chronic pain is a complex and debilitating condition affecting millions worldwide. Traditional management strategies often focus on medication invasive procedures, but growing evidence supports the role of exercise weight loss in chronic control. This manuscript provides detailed review current literature, discussing physiological mechanisms, benefits, recommendations as strategy for management...