introduction: colorectal cancer (crc) is one of the most prevalent cancers in the world. genetic disorders and dietary habits play a part in crc. the most important cancer suppressor gene is p53. different mutations rates in 7th exon of p53 gene are reported in different areas  which may have a relationship with prognosis of crc. this study examines the relationship between mutation in 7th exon...

Recently, the epigenetic modifications have been recognized as a regulator of gene expression in various cancers. EZH2 gene is one the most important component of the PRC2 complex. Overexpression of EZH2 was identified in multiple cancers that considered more attractive the EZH2 role as an oncogene. Some studies report that EZH2 contributes to various aspects of colorectal cancer (CRC). However...

Long noncoding RNAs (lncRNAs) have emerged as key components in multiple cellular processes, although their physiological and pathological functions are not fully understood. To identify cancer-related lncRNAs, we screened for those that are epigenetically silenced in colorectal cancer (CRC). Through a genome-wide analysis of histone modifications in CRC cells, we found that the transcription s...

background: hereditary non-polyposis colorectal cancer (hnpcc) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within iranian populations. we discuss in this article some molecular and clinicopathological features of the condition. methods: the study was a descriptive retrospective and designed on 1659 colorectal c...

Rising trends in incidence from colorectal cancer (CRC) young adults have been reported the United States and selected countries of Northern Europe Austral-Asia; corresponding cohort patterns were observed. 1 Siegel R.L. et al. J Natl Cancer Inst. 2017; 109 Google Scholar , 2 Sung J.J.Y. Am Gastroenterol. 2019; 114: 322-329 Crossref PubMed Scopus (37) 3 Vuik F.E. Gut. 68: 1820-1826 (186) In thi...

Patients with long-standing ulcerative colitis and Crohn’s disease have an increased risk of developing colorectal cancer and patients with small intestinal Crohn’s disease are at increased risk of small bowel adenocarcinoma. Colorectal cancer appearing on the ground of inflammatory bowel disease is the result of a process which is believed to begin from no dysplasia progressing to indefinite d...

Background : Impact of antithrombotics on the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening remains unclear. Methods Patients undergoing colonoscopy positive FIT in 2015 were assessed at 3 Belgian centers. Significant findings advanced polyps (AP) (sessile serrated, tubular or villous adenomas >1cm high-grade dysplasia) and CRC. False detection AP/CRC with calculated....

Colorectal cancer (CRC) is one of the most common cancers all over the world. It is essential to search for more effective diagnostic and therapeutic methods for CRC. Abnormal nicotinamide adenine dinucleotide (NAD) metabolism has been considered as a characteristic of cancer cells. In this study, nicotinamide mononucleotide adenylyl transferases (NMNATs) as well as p53-mediated cancer signalin...

BACKGROUND Colorectal cancer (CRC) is one of the most common cancer and the leading causes of cancer mortality worldwide. The critical role of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) are important in the cancer development. METHODS The purpose of this study was to investigate the association of miR-199a expression in CRC and non-tumor tissues as well...

Gastrointestinal cancer is a prevalent disease with high morbidity and mortality. Tissue factor pathway inhibitor 2 (TFPI2) gene could protect the extracellular matrix of cancer cells from degradation and tumor invasion. The goal of our study was to estimate the diagnostic value of TFPI2 hypermethylation in gastric cancer (GC) and colorectal cancer (CRC). TFPI2 methylation was measured by quant...