Our aim was to evaluate the short and long term efficacy of botulinum toxin therapy in Iranian patients with achalasia. In a randomized, double blind trial, 20 patients with achalasia, referring to Imam Khomeini Hospital, received either 80 units of botulinum toxin (BT) or placebo (PL) from 1995 to 1998. Two weeks later, the response to treatment was assessed on the basis of changes in the...

Background: Microdermabrasion has recently become a popular procedure among physicians and patients, whereas few studies have assessed the efficacy of different microdermabrasion protocols nowadays applied.The objective of this study was to assess the effects of microdermabrasion, as well as to compare the effects of weekly and biweekly intervals of microdermabrasion sessions on skin biophysica...

lamotrigine has been used widely in the treatment of partial and secondary generalized seizures. in this study use of lamotrigine as monotherapy for the newly diagnosed primary generalized tonic–clonic seizure has been investigated and compared with carbamazepine. after dose escalation (3 weeks for carbamazepine and 6 weeks for lamotrigin), patients were followed every 4 weeks for the first 16 ...

a recent randomized clinical trial showed buspirone efficacy in the treatment of attention-deficit/hyperactivity disorder (adhd) in children. however, results from a recent multi-site controlled clinical trial of transdermal buspirone failed to separate it from placebo in a large sample of children with adhd. therefore, due to these inconsistent findings, this study was designed to assess the e...

background: in clinical trials of irritable bowel syndrome (ibs), evaluation of treatment efficacy is still mainly subjective.we compared three outcome measures in reflecting response to treatment in a clinical trial of ibs. â  materials and methods: sixty three adult ibs patients participated in a placebo-controlled trial of 10-wk cognitive-behavioral therapy. patients completed the ibs-qualit...