PURPOSE To determine the main causes of intrastromal corneal ring segment (ICRS) explantation and the relationship with the microscopic findings on the ICRS surface. SETTING Vissum Corporation-Instituto Oftalmológico de Alicante, Alicante, Spain. METHODS This study evaluated ICRS that were explanted in centers in Spain from 2000 to 2008. Clinical data (reasons for explantation, date of impl...

BACKGROUND To investigate the molecular defects in a four-generation Chinese pedigree affected with Thiel-Behnke corneal dystrophy (TBCD). And to further study the relationship between genetic mutation and clinical manifestations. METHODS Individuals of the pedigree were recruited for extensive ophthalmic examinations. Histological studies of two corneal buttons obtained from lamellar keratop...

To evaluate the use of photorefractive keratectomy (PRK) with mitomycin C (MMC) application as a therapeutic and refractive solution for low to moderate myopic patients with granular corneal dystrophy (GCD) type 1, to study the postoperative complications and the recurrence rate, and to answer this question: Can excimer laser ablation obviate the need for keratoplasty in those patients?. Prospe...

The purpose of this study was to evaluate the effects of different time combinations of dexamethasoneand acetylcysteine on experimentally induced corneal ulcers in dogs. Experimental corneal wounds werecreated surgically to the anterior one third of the cornea in the center of all eyes of 15 mixed breed dogs. The eyes were divided into five groups according to planned post-operative medications...

purpose: to study the effect of phototherapeutic keratectomy (ptk) in the treatment of various superficial corneal pathologies. methods: we performed a nonrandomized, prospective study on patients who presented with superficial corneal disease and/or poor vision. fifty eyes were included recurrent corneal erosion (rce): 25 eyes, salzmann’s nodular degeneration: 9 eyes, spheroidal degeneration: ...

purpose: congenital corneal leukoma is rare with an incidence of 6/100000 and is one of the most important causes of amblyopia. here we report an unusual case of bilateral congenital elevated corneal leukoma. methods: we encountered a 13-day-old full term male newborn. ocular examination of both eyes revealed central elevated corneal leukomas with a narrow normal lucid interval to limbus. corne...

Report keratoconus in two patients with a long history of wrestling without any risk factor for corneal ectasia and reviewing the possible pathogenesis. To confirm suspicion of keratoconus, corneal topography was performed using scanning slit topography system and Orbscan. In two wrestlers with the complaint of visual loss in their eyes and IOP raising, corneal topography was performed and de...

BACKGROUND Second Harmonic Generation (SHG) microscopy recently appeared as an efficient optical imaging technique to probe unstained collagen-rich tissues like cornea. Moreover, corneal remodeling occurs in many diseases and precise characterization requires overcoming the limitations of conventional techniques. In this work, we focus on diabetes, which affects hundreds of million people world...