Cortical activity, as recorded via electroencephalography, has been linked to the refractive error of an individual. It is however unclear which optical metric modulates this response. Here, we measured simultaneously brain activity and retinal defocus a visual stimulus perceived through several values spherical blur. We found that, contrary existing literature on topic, cortical response funct...

NOTUM produced by osteoblasts is known to regulate cortical bone mass. Our new findings show that specifically derived DMP1-expressing osteocytes and late regulates mass not trabecular

To obtain drugs which are more selective at benzodiazepine (BZD) receptors, design and synthesis of functionally selective ligands for BZD receptors is the current strategy of our pharmaceutical chemistry department. The affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. Based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

  Background: Scaphoid malunion alters the carpal kinematics and impairs clinical outcome because of pain, weakness, restricted range of motion and predisposing the wrist joint to early osteoarthritis. The aim of this study was to evaluate the influence of the scaphoid morphological angles on clinical outcomes in patients with reconstructed scaphoid by non-vascularized bone graft. Methods: Seve...

Background Cryopreservation of ovarian cortex is increasingly used to preserve fertility before cancer therapy. Recently, studies show that Brain-derived neurotrophic factor (BDNF) may be involved in oocyte maturation. Brain-derived neurotrophic factor (BDNF) is member of neurotrophin family that has anti-apoptotic effects on nervous system. Recent researches show that it also plays key role in...

Motor responses evoked by transcranial magnetic stimulation OMS) or transcranial electrical stimulation (TCS) can be facilitated by a prior conditioning stimulus to an afferent nerve. Two facilitation periods are described short (SI), when the nerve stimulus is given near 0 to 10 ms after cranial stimulation, and long (LI), when nerve stimulation is given 25-60 ms before the cranial stimula...

introduction: the possible effect of postnatal chemically induced hypothyroidism on nadph- diaphorase containing neurons in different cortical areas of rat neonates. materials and methods: after parturition, dams divided in two groups. the control group receiving drinking water, and experimental group receiving 0.1% ptu in their drinking water. in different postnatal days (p4, p7, p10, p15, p23...

introduction: systemic application of capsaicin to neonatel rodents depletes their primary afferent c-fibers and also results in a wide variety of changes observable in adulthood. the manual methods used for stimulation of vibrissa provide limited information on response properties of barrel cortical neurons. in this study the effect of c-fiber depletion induced by neonatal capsaicin (cap) trea...