To the Editor: Iervasi et al1 report a strong correlation between low free biologically active triiodothyronine (fT3), a thyroid hormone, and all-cause and cardiovascular mortality in 573 consecutive patients with heart disease. The observations in this study are stimulating and may be of major clinical interest. However, the following points deserve to be clarified for better appreciating the ...

To the Editor: Iervasi et al1 report a strong correlation between low free biologically active triiodothyronine (fT3), a thyroid hormone, and all-cause and cardiovascular mortality in 573 consecutive patients with heart disease. The observations in this study are stimulating and may be of major clinical interest. However, the following points deserve to be clarified for better appreciating the ...

OBJECTIVES Despite growing evidence that arterial stiffness has important predictive value for cardiovascular disease in patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mildly impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on cardiova...

There are several statistical methods for time-to-event analysis, among which is the Cox proportional hazards model that is most commonly used. However, when the absolute change in risk, instead of the risk ratio, is of primary interest or when the proportional hazard assumption for the Cox proportional hazards model is violated, an additive hazard regression model may be more appropriate. In t...

BACKGROUND Lung infection by various organisms is a characteristic feature of cystic fibrosis (CF). CFTR genotype effects acquisition of Pseudomonas aeruginosa (Pa), however the effect on acquisition of other infectious organisms that frequently precede Pa is relatively unknown. Understanding the role of CFTR in the acquisition of organisms first detected in patients may help guide symptomatic ...

Inhibitors selective for prostaglandin G/H synthase-2 (PGHS-2) (known colloquially as COX-2) were designed to minimize gastrointestinal complications of traditional NSAIDs--adverse effects attributed to suppression of COX-1-derived PGE2 and prostacyclin (PGI2). Evidence from 2 randomized controlled-outcome trials (RCTs) of 2 structurally distinct selective inhibitors of COX-2 supports this hypo...

Global change is expanding the ecological niche of mixed-severity fire regimes into ecosystems that have not usually been associated with wildfires, such as temperate forests and rainforests. In contrast to stand-replacing fires, fires may result in delayed tree mortality driven by secondary factors post-fire environmental conditions. Because these effects vary a function time post-fire, their ...

OBJECTIVES The goal of this report is to present an individual patient's survival estimation curve using the each institution's survival data after Cox proportional hazard analysis. METHODS The program was developed in three parts: input of basic data from Cox proportional hazard analysis, input of individual patient's covariates, and presentation of individual patient's survival curve. In th...

Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population-based study in which Parkinson's disease patients who were not ascertained through medical practitio...

The recent literature on the duration of trade has predominantly analyzed the determinants of trade flow durations using Cox proportional hazards models. The purpose of this paper is to show why it is inappropriate to analyze the duration of trade with continuous-time models such as the Cox model, and to propose alternative discrete-time models which are more suitable for estimation. Briefly, t...