Cetuximab-induced nephrotoxicity is very rare, occurring in less than 1% of colorectal cancer patients and not defined in other populations. We report a rare case of crescentic diffuse proliferative glomerulonephritis (GN) that developed in close temporal association with cetuximab treatment. A 65-year-old female recently completed chemotherapy with cetuximab treatment for moderately differenti...

OBJECTIVE To determine the etiology, course and predictors of outcome in children with crescentic glomerulonephritis (GN). STUDY DESIGN Retrospective, descriptive study. SETTING Pediatric Nephrology Clinic at a referral center in Northern India. METHODS Clinic records of patients aged <18 year with crescentic GN diagnosed from 2001 - 2010 and followed at least 12 months were reviewed. Cre...

Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multiple organ involvement. Lupus nephritis (LN) is a common manifestation with a wide variety of histological appearances. Matrix metalloproteinases (MMP) 2 and 9 are gelatinases capable of degrading glomerular basement membrane type IV collagen, which have been associated with LN. We examine the e...

Despite the critical role that TGFplays in renal fibrosis, transgenic mice that overexpress human latent TGF1 in the skin exhibit normal renal histology and function even though circulating levels of latent TGF1 are an order of magnitude higher than wild-type animals. In fact, latent TGF1 seems to protect against renal inflammation in a model of ureteral obstruction. It is unknown, however, whe...