Although 1,25-dihydroxyvitamin D3 stimulates osteoclastic bone resorption in vivo and in organ culture, the mechanism by which it effects this stimulation is unknown. We have recently found that the agent does not stimulate resorption by osteoclasts mechanically disaggregated from bone and incubated on slices of cortical bone. This suggests that the osteoclasts were removed by disaggregation fr...

OBJECTIVE The objective of this study was to clinically and radiographically assess the peri-implant conditions of implants used as orthodontic anchorage. METHODS Two groups were studied: 1) a test group in which osseointegrated implants were used as orthodontic anchorage, with the application of 200-cN force; and 2) a control group in which implants were not subjected to orthodontic force, b...

STATEMENT OF PROBLEM Although the implant-abutment connection may prevent crestal bone loss around dental implants, its failure often leads to treatment failure. Microgap and micromovement of the implant-abutment connection could be causes of bone resorption around dental implant neck. PURPOSE The purpose of this study was to compare torque resistance and microgaps between a new cone and inde...

OBJECTIVES In contrast to the excellent long-term outcomes described for implant-supported mandibular overdentures, less favorable long-term survival and success rates have been reported for maxillary implants supporting overdentures. The aim of this study was to evaluate the treatment outcome of "planned" bar-retained maxillary and mandibular overdentures supported by Morse taper connection im...

Osteoporosis is one of the most common bone pathologies, which are characterized by a decrease in bone mass. It is well established that bone mass, which results from a balanced bone formation and bone resorption, is regulated by many hormonal, environmental and genetic factors. Here we report that the immune semaphorin 4D (Sema4D) is a novel factor controlling bone resorption. Sema4D-deficient...

Methods: Light-hardened poly-methyl-methacrylate, poly-hydroxyl-ethyl-methacrylate, and calcium hydroxide plus polyanhydride (PPCH+PA) composite graft), PPCH graft alone, PA graft alone, were compared to each other and to a no graft control group. All mandibular premolar teeth were extracted; a total of 48 implants were placed into sockets of the mesial roots in three minipigs. Crestal areas an...

The conventional placement protocol for submerged and non-submerged implants was proposed in the 1960s and 1970s. Multicenter studies have reported satisfactory success rates for both protocols and a similar loss of crestal peri-implant bone after implant loading (0.5 to 1.5 mm). In recent years, placement of submerged implants using a single surgical procedure was introduced, with the immediat...

PURPOSE To evaluate the survival, success, and complication rates of tapered double-lead threads single implants, placed in fresh extraction sockets and healed sites of the posterior jaws. METHODS The enrolled patients were randomly divided into 2 groups: in the test group (TG), all implants were inserted at the time of tooth extraction; in the control group (CG), all implants were placed 3 m...

PURPOSE Renal osteodystrophy is a common complication of chronic renal failure and renal replacement therapy. Successful kidney transplantation reverses many of these abnormalities, however, the improvement is often incomplete. The osteoclast specific 5b isoform of tartrate-resistant acid phosphatase (TRAP) 5b has recently been proposed a specific and sensitive marker of bone resorption. The ai...