Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into any mesenchymal tissue, including bone, cartilage, muscle, and fat. MSC differentiation can be influenced by a variety of stimuli, including environmental and mechanical stimulation, scaffold physical properties, or applied loads. Numerous studies have evaluated the effects of vibration or cyclic tensile strain ...

cyclic loading in the early postoperative period might affect a sutured graft function. The objective of this study is to test the hypothesis that suturing of a tendon graft may affect the material properties of the corresponding tendon site, due to local changes in tendon matrix composition. Several digital flexor tendons were armed with a whipstitch and examined under tension or cyclic loadin...

Surfactin, a bacterial cyclic lipopeptide, is produced by various strains of Bacillus subtilis and is primarily recognized as one of the most effective biosurfactants. It has the ability to reduce surface tension of water from 72 to 27 mN/m at a concentration as low as 0.005 %. The structure of surfactin consists of seven amino acids bonded to the carboxyl and hydroxyl groups of a 14-carbon fat...

Abstract: In this paper, a systematic numerical simulation was performed to elucidate the damage mechanisms in bulk metallic glasses (BMGs) subjected to the tension-compression cyclic loading, and then the relation between fatigue life, applied strain, and cycling frequency was therefore presented. The free volume was selected as an internal state variable to depict the shear-band nucleation, g...

Mechanical stimulation is known to regulate the calcification of endplate chondrocytes. The ANK protein has a strong influence on anti-calcification by transports intracellular inorganic pyrophosphate (PPi) to the extracellular. It is known that TGF-β1 is able to induced Ank gene expression and protect chondrocyte calcification. Intermittent cyclic mechanical tension (ICMT) could induce calcifi...

The objective of the paper is to study the effect of cyclic loading on the fracture resistance of the SA 333 Gr.6 carbon steel material of the primary heat transport (PHT) system piping of Indian pressurized heavy water reactors (PHWR). Tests have been carried out on compact tension specimens machined from the pipe used in the PHT system. The effect of load ratio, incremental plastic displaceme...

In a previous communication, we showed that 3-adrenergic stimulation of cardiac muscle was associated with an increase in the rate of cycling of crossbridges as measured by perturbation analysis in the frequency domain. In this analysis, the frequency at which dynamic stiffness is a minimum (f.in) is taken as a measure of the rate of crossbridge cycling. In this paper, we test the hypothesis th...

We designed experiments to characterize the role of superoxide anions in the mediation of endothelium-dependent contractions in isolated canine basilar arteries. Rings with and without endothelium were suspended for isometric tension recording in Krebs-Ringer bicarbonate solution bubbled with 94% O2-6% CO2 (37 degrees C, pH 7.4). Radioimmunoassay was used to determine the levels of cyclic GMP a...

In a previous communication, we showed that 3-adrenergic stimulation of cardiac muscle was associated with an increase in the rate of cycling of crossbridges as measured by perturbation analysis in the frequency domain. In this analysis, the frequency at which dynamic stiffness is a minimum (f.in) is taken as a measure of the rate of crossbridge cycling. In this paper, we test the hypothesis th...

Introduction: Bone marrow stromal cells (BMSCs) are an attractive cell source for fibrocartilage repair due to their multipotency and availability. Previous studies have shown that transforming growth factor β1 (TGF-β1) and dexamethasone stimulate the chondrogenesis of BMSCs in 3D culture[1], but the types or combinations of signals required to drive fibrochondrocyte differentiation remain uncl...