BACKGROUND CD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as resistance to chemotherapeutic agents and ionizing radiation; however, their function remains unknown. In this paper, we identified a hitherto unknown mechanism to overcome CD133-induced resistance to anticancer therapy. METHODS We applied an alternative approach to enri...

abstract in this study the relationship among perfectionism, defense styles and depression symptoms was studied. participants were 426 undergraduate students from the university of guilan (264 females, 162 males), who were selected through randomized clustering multistage method. all participants were asked to complete the multidimensional perfectionism scale (hewitt & flett, 1991), the defense...

BACKGROUND Our understanding of coevolution in a predator-prey system is based mostly on pair-wise interactions. METHODOLOGY AND PRINCIPAL FINDINGS Here I analyze a one-predator-two-prey system in which the predator's attack ability and the defense abilities of the prey all evolve. The coevolutionary consequences can differ dramatically depending on the initial trait value and the timing of t...

The objective of this study was to evaluate the effect of dietary supplements with lead acetate and aluminosilicates (ATN) on antioxidative enzyme activities and lipid peroxidation of the heart and skeletal muscle tissues of broiler chickens. Broilers were allotted to four diets including the control group, the Pb group, the aluminosilicate-ATN (antitoxic nutrient) group and the Pb+ATN group, i...

The new cyber attack pattern of advanced persistent threats (APTs) poses a serious threat to cyberspace. This paper addresses the issue of defending against APTs in a cost-effective way. First, the APT-based cyber attack-defense processes are modeled as a type of differential dynamical systems. Then, the cyber defense problem is modeled as an optimal control problem. The optimal control problem...

Game theory has been researched extensively in network security demonstrating an advantage of modeling the interactions between attackers and defenders. Game theoretic defense solutions have continuously evolved in most recent years. One of the pressing issues in composing a game theoretic defense system is the development of consistent quantifiable metrics to select the best game theoretic def...

toll like receptors (tlrs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens. in their bridging role, tlr downstream signals link innate and adaptive immunity, particularly by mediating dc maturation and activation of pathogen specific t lymphocytes. these pathways lead to the act...