The transport characteristics and regulation of the Na/K/Cl cotransport system were investigated in cultured human fibroblasts (HSWP cells). The existence of the system was documented by the finding that digitoxin-insensitive K+ influx was dependent upon the presence of both Na+ and Cl- in the extracellular milieu. It was found that only Br- could partially substitute for Cl-, with SCN-, I-, ac...

Despite significant advances in the understanding of lung cancer biology, the prognosis of cancer patients remains poor. Part of the failure of anticancer therapy is due to intratumoral heterogeneity in these patients that limits the efficacy of single agents. Therefore, there is an urgent need for new anticancer drugs or drug combination regimens that possess increased activity against all cel...

A 78-year-old woman presented to the emergency room complaining of a 2-week history of general fatigue and increasing weakness in both legs. She also experienced an irregular heartbeat and had slight dyspnea. She had had a cardiac syncope 1 year earlier and received a pacemaker (VVI mode). The woman reported a history of arterial hypertension and mild chronic heart failure. Because of previous ...

1 Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, NY, USA, 11724 2 Department of Applied Mathematics & Statistics, Stony Brook University, Stony Brook, NY 11794 3 Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD, USA, 21205 4 Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, NY, USA, 11724 5 Departments of Comput...

It has been shown that, following treatment with ribo nuclease, there is a loss of net negativity at the surfaces of some cells due to the enzymatic action of the RNase. These and other experimental data have been interpreted to indicate the presence of RNA as a structural component of the cell periphery (8, 19—21). It has been speculated that this peripheral RNA could play a part in cell rec...