The mobility of cell surface MHC molecules and their ability to form dynamic associations may be related to the physiological status of the cell and to the potential to bind effector T lymphocytes. To investigate these properties, we have prepared HLA DR specific monoclonal antibodies coupled in a 1:1 mole ratio to the fluorescent phycobiliprotein, R-phycoerythrin (PE). We show that these small...

It is now well established that cell interiors are significantly crowded by macromolecules, which impede diffusion and enhance binding rates. However, it is not fully appreciated that levels of crowding are heterogeneous, and can vary substantially between subcellular regions. In this article, starting from a microscopic model, we derive coupled nonlinear partial differential equations for the ...

Macromolecular transport through the interstitial space of a tissue occurs by convection and diffusion. The convective component of transport results from interstitial fluid flow. There have been no direct measurements of the magnitude or direction of interstitial fluid flow in tissues to date. Using fluorescence recovery after photobleaching, we have measured interstitial fluid velocities and ...

It is difficult to obtain accurate prediction results of cascades over online social networks, therefore a variety of diffusion models have been proposed in the literature to simulate diffusion processes instead. We argue that such models require extensive simulation results to produce good estimates of future spreads, while at the same time requiring training over observed data to learn the pa...

The kinetic energy of an adatom during its impact with a growth surface significantly affects the morphology and microstructure of vapor-deposited films and coatings. Atomic-scale reconstruction processes including ‘athermal’ and ‘biased’ diffusion are in part responsible. A three-dimensional molecular dynamics method has been used to characterize the extent of these diffusional processes follo...

We demonstrate that an exact analytical solution can be constructed for an intracellular directed transport model ofintegrin developed by Schmidt et al. (1994) The model attempts to mimick the experimental observation that integrin is transported intermittently, by a combination of two-dimensional diffusion and cytoskeleton-mediated convective transport, towards the cell edge In particular, the...

The current diffusion-retention model for protein trafficking to the inner nuclear membrane (INM) proposes that INM proteins diffuse laterally from the membrane of the endoplasmic reticulum into the INM and are then retained in the INM by binding to nuclear proteins or DNA. Because some data indicate that the sorting of baculovirus envelope proteins to the INM is protein-mediated, we have exami...

materials and methods the segmentation process is evaluated using four different clustering methods with different number of clusters where some dti scalar indices for 10 human brains are processed. results the aim was to produce results with less segmentation error and a lower computational cost while attempting to minimizing boundary overlapping and minimizing the effect of artifacts due to m...