We report a novel strategy to construct temperature-responsive nanocarriers for controlled release based on mesoporous silica and reversible single-stranded DNA valves.

The kinetics of the reaction between double stranded DNA (dsDNA) and formamide is monitored at the single DNA molecule level. We find that stretching of the DNA leads to an accelerated reaction rate and to a shift in the final equilibrium concentrations. The larger the stretching force, the faster the reaction and the larger the denatured fraction of the product DNA. The single molecule kinetic...

background: the poor permeability of the plasma and nuclear membranes to dna plasmids are two major barriers for the development of these therapeutic molecules. therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. objectives: the aim of this study was to investigate the in vitro delivery of plasmid dna encoding hpv16 e7 gene ...

This paper shows how to use DNA strands to construct solution space of molecules for the dominating-set problem and how to apply biological operations to solve the problem from the solution space of molecules. In order to achieve this, we have proposed some DNA based parallel algorithms using the operations in Adleman–Lipton model, together with the analysis of the computational complexity for ...

Microcin B17 is a peptide antibiotic that inhibits DNA replication in Escherichia coli by targeting DNA gyrase. Previously, two independently isolated microcin B17-resistant mutants were shown to harbor the same gyrB point mutation that results in the replacement of tryptophan 751 by arginine in the GyrB polypeptide. We used site-directed mutagenesis to construct mutants in which tryptophan 751...

Nanostructures that display controllable motions and functions are indispensable to build molecular nanomachines. Structural DNA nanotechnology, enabling precise design of complex static dynamic structures, can be used construct However, designing structures present multiple motion behaviors with different stimuli-responsiveness is full challenges. Herein, multistep transformations origami domi...

A DNA representation of Boolean logic for which the input strands are separate from the operator strands is described and used to construct a two-bit DNA adder. The successful operation of the adder for several test inputs demonstrates that digital molecular computation with a complexity of order 30 gates is feasible.

DNA possesses many desirable chemical/physical properties as a polymeric material. With the myriad of tools available to manipulate DNA, there is great potential for using DNA as a generic instead of a genetic material. Although much progress has been made in DNA computing and DNA nanotechnology, the full achievement of DNA-based materials has not yet been realized. As almost all DNA molecules ...