objective: in this project, our aim was to construct a novel expressing vector harboring a new sequence from overlapping region of ns3 gene of hcv from infected iranian patient. materials and methods: the partial ns3 (pns3) gene was amplified by nested-rt-pcr method using sera of hcv infected patients harboring genotype 1a. after purification and cloning the pns3 into ta-cloning vector, the be...

background: it seems that the success of vaccination for cancer immunotherapy such as dendritic cell (dc) based cancer vaccine is hindered through a powerful network of immune system suppressive elements in which regulatory t cell is the common factor. foxp3 transcription factor is the most specific marker of regulatory t cells. in different studies, targeting an immune response against regulat...

Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. Objective: To evaluate the use of a DNA immunization strategy for protection against anthrax, a plasmid was constructed. Methods: The partialsequence of protective antigen of Bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...

This article is devoted to two different generalizations of projective Boolean algebras: openly generated Boolean algebras and tightly σ-filtered Boolean algebras. We show that for every uncountable regular cardinal κ there are 2 pairwise non-isomorphic openly generated Boolean algebras of size κ > א1 provided there is an almost free non-free abelian group of size κ. The openly generated Boolea...

In large process deployments where an enterprise has to model and maintain a large number of processes that are specializations of each other it is advantageous to provide formal support for process specialization called process inheritance. A process inheritance model definition is introduced as well as a process definition language construct for defining process specialization.

In this paper we address object-oriented component integration issues. We argue that traditional framework customization techniques are inappropriate for component-based programming since they lack support for non-invasive, encapsulated, dynamic customization. We propose a new language construct, called a pluggable composite adapter, for expressing component gluing. A pluggable composite adapte...

background: dna immunization with plasmid dna encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. objective: to evaluate the use of a dna immunization strategy for protection against anthrax, a plasmid was constructed. methods: the partialsequence of protective antigen of bacillus anthracis, amino acids 175-764, as a potent immunogenic targe...

In a recent project the Ada language turned out to be not as flexible as we expected it to be. This forced us to model our application in a way that was less elegant, less maintainable and less efficient. In this paper we propose to add a language construct to the language that would enable us to do what we were missing. The extension is based on finite unions with dispatching and can quite eas...

A hyperbolic bration is set of q ?1 hyperbolic quadrics and two lines which together partition the points of PG(3; q). The classical example of a hyperbolic bration comes from a pencil of quadrics; however, several other families are known. In this paper we construct a new family of hyperbolic brations for odd prime powers q. As an application of hyperbolic brations, we note that they can be us...

This paper studies the information content of some Ifo indicators. In particular, we investigate whether two Ifo indicators, one on the current business situation, the other on current production development, provide information on revisions of German industrial production. A new feature of our analysis is the construction and use of a real-time dataset. We conclude that the Ifo indicators play...