in the course of an evaluation of various schistosomicidal drugs in iran, the effect of an organo-phosphorus compound in the-treatment of 45 mild cases of urinary bilhariziasis was assessed and the drug was given in 3 doses of 10 mg/kg body weight each with 3-week intervals. follow-up examinations undertaken 3 weeks after the 1st, 2nd and 3rd doses as well as 3 months after completion of therap...

Drug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics-pharmacodynamics associated with systemic therapies. For many drug therapies, there is potential to use the respiratory system as an alternative route for drug delivery. Aerosol drug delivery can provide many advantages over conventional therapy. Given that respiratory diseases are the commonest cause...

Inferring potential therapeutic indications and identifying clinically important side-effects are both important and challenging tasks in modern drug development. Previous studies have utilized drug chemical structures and protein targets to construct predictive models for both tasks. According to our study, the drug therapeutic information itself is highly predictive for side-effects, and drug...

Lithium is widely used in medicine as an anti-depressive drug. In spite of abundant literature, questions on the side effects of lithium ions are far from being answered. In this study, the effects of lithium on biochemical parameters related to lipid metabolism were investigated. Male Wistar rats were treated with different doses of lithium for a period of up to 60 days. Blood samples were col...

Five antiepileptic drugs have been marketed in the last decade. We report here a retrospective study of patients attending our unit who were prescribed one of the new antiepileptic drugs. All these patients had refractory localization related epilepsy and had failed to respond to a first-line drug. The drugs had a different profile of side-effects but topiramate (42%) was the most common drug t...

OBJECTIVE This work identified challenges associated with extraction and representation of medication-related information from publicly available electronic sources. METHODS We gained direct observational experience through creating and evaluating the Drug Evidence Base (DEB), a repository of drug indications and adverse effects (ADEs), and supplemented this through literature review. We extr...

Fulvestrant, the first drug of the pure estrogen antagonists to be approved for clinical use, is a new therapeutic option for metastatic breast cancer. Fulvestrant offers a unique metastatic breast cancer treatment option because its mechanism of action is the destruction, rather than the blockade, of estrogen receptors. No known agonistic activity exists, limiting potential side effects and re...

Cisplatin (cis-diamine-dichloroplatinum (II), CDDP) is a prominent member of the effective broad-spectrum antitumor drugs. However, its clinical usage restricted due to serious side effects particularly nephrotoxicity. The vulnerability kidney CDDP almost certainly related primary role in excretion drug as intact and platinum containing products are excreted mainly urine. There correlation betw...