Abstract Bis‐ethynylphosphonamidates allow for a simple chemoselective addition of two thiol‐containing modules in row. We describe four such bis‐electrophiles that carry different functional O‐substituents with tunable hydrophilicity and enable further subsequent conjugations, thus facilitating protocol constructing protein‐protein conjugates. An increased spacer length between the ethynylphos...

The night-time economy (NTE) provides many opportunities for crime as there is an abundance of potential victims who are often intoxicated and clustered in a small geographical area. Previous research on NTE violence has primarily focused assault. However, other offences also common, such robbery. This study NTE-related robbery using police recorded data relating to 1624 personal robberies (inc...

Vascular endothelium plays strategic roles in many drug delivery paradigms, both as an important therapeutic target itself and as a barrier for reaching tissues beyond the vascular wall. Diverse means are being developed to improve vascular drug delivery including stealth liposomes and polymer carriers. Affinity carriers including antibodies or peptides that specifically bind to endothelial sur...

Two-pore domain potassium channels, like KCNK2, are known to play an important role in inflammatory diseases such as multiple sclerosis (MS). Upregulation of cellular adhesion molecules in mouse brain microvascular endothelial cells (MBMECs) of Kcnk2-/- mice resulted in elevated leukocyte trafficking into the central nervous system under inflammatory conditions. The current project aims to gain...

We evaluate the deterrence effects of age criminal responsibility on total drug trafficking and homicide crimes per age, based a quasi-experiment generated by differences in punishment severity for these prescribed Statute Child Adolescent Penal Code Brazil. To this end, information from arrests conducted civil military police Rio de Janeiro 2016 2017 is used to estimate local treatment through...

The article updates the problem of drug situation in Russia, examines consequences COVID–19 pandemic segment youth audience, analyzes trend 2019–2021 associated with trafficking social networks through darknet. On basis a theoretical analysis, proposals are put forward terms joint actions law enforcement agencies, specialized structures local authorities and private mobile operators as whole fo...

This study examines the relationship between gun availability and crime in a cross-national sample of cities. Data from the International Crime Victimization Survey are used to examine three competing hypotheses. The results of the limited information maximum least squares regression analyses suggest that gun availability influences rates of assault, gun assault, robbery, and gun robbery. These...