background: clopidogrel is one of the most commonly prescribed drugs to prevent ischemic events following coronary syndromes or stent placement. however, impaired responses to therapy as well as resistance are also reported. genetic variants play an important role in clopidogrel biotransformation to its active metabolite that may subsequently influence the clopidogrel antiplatelet effect. the o...

conclusions polymorphism in the hemochromatosis gene may confer some degree of risk for hcv infection, and individuals carrying the h and c alleles may be susceptible to this disease; however, a larger sample of hcv patients and healthy individuals may be necessary to further illustrate the role of these polymorphisms in hcv. patients and methods hfe gene polymorphisms were examined in a total ...

it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...

this study was performed to investigate two polymorphic sites from cyp19 gene (pvuii and mspi) and one polymorphic site from erα gene (snabi) in four cattle breeds including mazandarani, taleshi, sistani and simmental. in overall 278 samples for cyp19 and 206 samples for erα marker sites were genotyped using polymerase chain reactionsingle-strand conformation polymorphism (pcr-rflp) procedure. ...

A total of 2,410 community residents aged 55 years and older were recruited from the Ningxia province of China. Apolipoprotein E (APOE) gene polymorphisms were detected using the high-resolution melting curve method. The Mini-Mental State Exam and Duke University Religion Index were administered to assess cognitive function and religiosity. The logistic regression model was used to examine the ...

3547 Identification of Nonproliferating but Viable Hypoxie Tumor Cells in Vivo. Ralph E. Durand and James A. Raleigh. Epidemiology and Prevention 3603 The Role of JV-Acetylation Polymorphisms in Smoking-associated Bladder Cancer: Evidence of a Gene-Gene-Exposure Three-Way Interaction. Jack A. Taylor, David M. Umbach, Elizabeth Stephens, Trisha Castranio, David Paulson, Gary Robertson, James L. ...

Introduction:Gastrointestinal cancers constitute more than one-third of the most common cancers and half of the fatal cancers worldwide. Toll-like receptors (TLRs) are identified as pivotal receptors in innate immunity responses. TLR4 is the main receptor that plays a role in lipopolysaccharide  (LPS)  sensing  of  gram-positive  bacteria.  D299G  (rs4986790)&...

Introduction:Gastrointestinal cancers constitute more than one-third of the most common cancers and half of the fatal cancers worldwide. Toll-like receptors (TLRs) are identified as pivotal receptors in innate immunity responses. TLR4 is the main receptor that plays a role in lipopolysaccharide  (LPS)  sensing  of  gram-positive  bacteria.  D299G  (rs4986790)&...

UNLABELLED Hepatitis E viral (HEV) infection imposes a heavy health burden worldwide and is common in the United States. Previous investigations of risks addressed environmental and host behavioral/lifestyle factors, but host genetic factors have not been examined. We assessed strength of associations between antibody to HEV (anti-HEV) immunoglobulin G seropositivity indicating past or recent H...

Abstract The results of the study showed two genetic polymorphisms BM4505 marker for studied samples: 270/260, 280/271 bp, their distribution ratio was 60.34 and 39.66 %, respectively, which highly significant differences (P≤0.01) among polymorphisms. that there were (P≤0.05) between 270/260,280/271 bp by California mastitis test, cows carrying 270/260 where test value 1.20 on 2.47, as other tr...