Neutrophil accumulation at sites of inflammation is mediated by specific groups of cell adhesion molecules including the b2 (CD18) integrins on leukocytes and the selectins (Pand E-selectin on the endothelium and L-selectin on the leukocyte). This is supported by studies of patients with leukocyte adhesion deficiency syndromes whose leukocytes are genetically deficient in the expression of b2 i...

Neutrophil accumulation at sites of inflammation is mediated by specific groups of cell adhesion molecules including the beta2 (CD18) integrins on leukocytes and the selectins (P- and E-selectin on the endothelium and L-selectin on the leukocyte). This is supported by studies of patients with leukocyte adhesion deficiency syndromes whose leukocytes are genetically deficient in the expression of...

ACCOMPLISHMENTS (throughout the award period): We first established the model system for analyzing IgEand mast cell-dependent cutaneous allergic reactions in wild type (normal) mice of the correct genetic background (129/Sv x C57BL/6 mice), since the details of the methods needed for optimal analysis of such reactions can vary according to mouse strain. We then analyzed multiple features of IgE...

C.M. O'Brien CEF AS Lowestoft Laboratory Pakefield Road, Lowestoft Suffolk NR33 ORT United Kingdom fax: +441502513865 e-mail: [email protected] The investigation of stock-recruitment (S-R) relationships can result in functional models that are appealing when depicted in 2-dimensions as the level of recruitment versus spawning stock biomass. Translation of a functional S-R model to the thir...

Bone morphogenetic proteins 9 and 10 (BMP9/BMP10) are circulating cytokines with important roles in endothelial homeostasis. The aim of this study was to investigate the roles of BMP9 and BMP10 in mediating monocyte-endothelial interactions using an in vitro flow adhesion assay. Herein, we report that whereas BMP9/BMP10 alone had no effect on monocyte recruitment, at higher concentrations both ...

The perception of physician shortage in Canada is widespread. Absolute shortages and relative discrepancies, both specialty-wise and in urban-rural distribution, have been a daunting policy challenge. International Medical Graduates (IMGs) have been at the core of mitigating this problem, especially as long as shortage of physicians in rural areas is concerned. Considering such recruitment as h...

BACKGROUND Recruitment to clinical research studies can prove complex. This is particularly true of mental health research, given factors such as confidentiality, capacity and consent, or when attempting to recruit family members as opposed to service users themselves. AIM This study investigated the challenges experienced and strategies employed in the recruitment of siblings of people with ...

Walleye is a very common recreational fish in Canada with a strong cannibalism tendency, such that walleyes with larger sizes will consume their smaller counterparts when food sources are limited or a surplus of adults is present. Cannibalism may be a factor promoting population oscillation. As fish reach a certain age or biological stage (i.e. biological maturity), the number of fish achieving...