Computer-based tutoring systems that can coach students in solving introductory programming problems have significant potential for improving the quality of programming education and reducing the instructor’s work load. The purpose of this paper is to describe the current development status of the innovative Environment for Learning to Program (ELP) which provides an interactive webbased enviro...

PURPOSE We define the ideal anterior capsulotomy through consideration of capsular histology and biomechanics. Desirable qualities include preventing posterior capsular opacification (PCO), maintaining effective lens position (ELP) and optimising capsular strength. METHODS Laboratory study of capsular biomechanics and literature review of histology and published clinical results. RESULTS Pa...

Biosynthetic strategies for the production of recombinant elastin-like protein (ELP) triblock copolymers have resulted in elastomeric protein hydrogels, formed through rapid physical crosslinking upon warming of concentrated solutions. However, the strength of physically crosslinked networks can be limited, and options for non-toxic chemical crosslinking of these networks are not optimal. In th...

As the practical use of answer set programming (ASP) has grown with the development of efficient solvers, we expect a growing interest in extensions of ASP as their semantics stabilize and solvers supporting them mature. Epistemic Specifications, which adds modal operators K and M to the language of ASP, is one such extension. We call a program in this language an epistemic logic program (ELP)....

To solve the multi-stage linear programming problem, one may use a deterministic or a stochastic approach. The drawbacks of the two techniques are well known: the deterministic approach is unrealistic under uncertainty and the stochastic approach suffers from scenario explosion. We introduce a new scheme, whose objective is to overcome both drawbacks. The focus of this new scheme is on events i...

tRNA modifications are crucial to ensure translation efficiency and fidelity. In eukaryotes, the URM1 and ELP pathways increase cellular resistance to various stress conditions, such as nutrient starvation and oxidative agents, by promoting thiolation and methoxycarbonylmethylation, respectively, of the wobble uridine of cytoplasmic (tK(UUU)), (tQ(UUG)), and (tE(UUC)). Although in vitro experim...

Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within a tumor to selectively irradiate the tumor mass while minimizing systemic toxicity. To mitigate the disadvantages associated with complex surgical implantation and subsequent device removal procedures, we have developed an alternative approach using a genetically encoded peptide polymer solu...

The orphan nuclear receptor steroidogenic factor 1 (SF-1) is expressed in the adrenal cortex and gonads and regulates the expression of several P450 steroid hydroxylases in vitro. We examined the role of SF-1 in the adrenal glands and gonads in vivo by a targeted disruption of the mouse SF-1 gene. All SF-1-deficient mice died shortly after delivery. Their adrenal glands and gonads were absent, ...

In the eastern Tibetan plateau both human cystic and alveolar echinococcosis (AE) caused by infection with Echincoccus granulosus or Echinococcus multilocularis, respectively are highly endemic. The domestic dog plays a key role in zoonotic transmission in this region. Our primary objective was to investigate the role of domestic dogs in maintaining transmission of E. multilocularis in Shiqu co...