Steroid hormones are found to play a major role in the genesis and progression of mammary tumors. The aim of this study was to immunohistochemically detect the presence of estrogen receptor alpha (ER α ), estrogen receptor beta (ER β ), and progesterone receptor (PR) and also to study the association between these markers in 29 cases of benign (11) and malignant (18) canine mammary tumors. ER α...

Abstract Breast cancer is the most common with a high rate of mortality and morbidity among women worldwide. Estrogen receptor status an important prognostic factor endocrine therapy choice first-line treatment in ER-positive breast cancer. However, tumors develop resistance to therapy. Here we demonstrate that BH3 profiling technology, particular, dynamic can predict response agents as well de...

Background & Objective: Gliomas are the most common type of primary intracranial tumors in adults. The expression of estrogen receptors varies in different grades of glial tumors, and some studies have suggested that this expression might have a prognostic value. It seems that estrogen receptor expression negatively correlates with the histological grade of gliomas. In the pres...

Our understanding of the molecular mechanisms of renal magnesium (Mg) handling has greatly enhanced over recent years. This review highlights the regulatory factors controlling Mg homeostasis through its effects on the epithelial Mg channel TRPM6 (Transient Receptor Potential Melastatin subtype 6), the gatekeeper of the body’s Mg balance. Drug treatment, acid-base status, and several hormones h...

Estrogen Receptor alpha and beta (ER-α and -β) are members of the nuclear receptor family of transcriptional regulators with distinct roles in mediating estrogen dependent breast cancer cell growth and differentiation. Following activation by the hormone, these proteins undergo conformation changes and accumulate in the nucleus, where they bind to chromatin at regulatory sites as homo- and/or h...

OBJECTIVE To test whether estrogen receptor polymorphisms modify the effects of postmenopausal hormone therapy on biomarkers and on risk of coronary heart disease events, stroke, or venous thromboembolism. METHODS AND RESULTS The design was a nested case-control study in the Women's Health Initiative trials of postmenopausal hormone therapy. The study included all cases in the first 4 years: ...

Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related co...

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

in human breast cancer, estrogen receptor (er) status of the tumor has prognostic and therapeutic significance. however, facilities to study er are not widely available to us. we postulated that if there is a correlation between histologic grade and er status of invasive ductal carcinoma (idc), it may help predict the er status of the tumor. of 8 4 cases of breast carcinoma referred to the canc...