Mohamad Tavakoli

Associate Professor of physiology, Department of physiology-pharmacology, Rafsanjan University of Medical Science, Rafsanjan, Iran

[ 1 ] - Comparison of the Effects of Relaxation and Vitamin B6 on Emotional and Physical Symptoms in Premenstrual Syndrome

Background: Premenstrual syndrome (PMS) is consisted of multiple psychological and emotional symptoms. This disorder possesses adverse effects on women’ economic, social, familial and professional issues, therefore various medical therapies have been suggested, thus all have own side effects. Aim: To compare the effects of relaxation and vitamin B6 on emotional and physical symptoms of PMS. Met...

[ 2 ] - CX691 as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’s disease

Objective(s): Growing evidence suggests that dysfunction of the glutamatergic system and α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptors are involved in pathology of Alzheimer’s disease (AD). Because AMPA receptors play a key role in plasticity synaptic regulation, positive modulation of these receptors may rescue the cognitive deficits in the AD. The aim of this study was ...

[ 4 ] - Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex

Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for waterinsoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10% v/v concentration and injected into the later...

[ 5 ] - Vitex Agnus Castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor α in Hippocampus of Ovariectomized Rats

Introduction: Lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. Although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. Phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related co...

[ 6 ] - Effect of the hydroalcoholic extract of pistachio on avoidance learning in male Wistar rats

Background: Pistachio is a plant that has long been cultivated in different parts of Iran. Pistachios are very nutritious and contain vitamins E and B, flavonoids, antioxidants, and carotenoids. Since the pistachio is effective in the treatment of some neurological disorders and is indigenous to Iran and considering the substantial use of this nut, it is necessary to investigate its effects on ...

[ 7 ] - A two-year survey on the effect of temperature changes on the incidence of myocardial infarction in patients referred to the Ali-ibn Abi Talib Hospital, Rafsanjan, Iran, in 2013-2014

Background: The role of temperature changes, as an environmental risk factor, in the human health status has been investigated in recent studies. Accordingly, the present two-year study was conducted to evaluate the incidence of myocardial infarction (MI) in warm and cold seasons in Ali-ibn Abi Talib Hospital, Rafsanjan, Iran. Materials and Methods: In this descriptive and cross-sectional st...

[ 8 ] - Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion

Objective(s): Previous studies have indicated that phytoestrogens induce estrogenic as well as anti-inflammatory effects, and they are found in high abundance in the extracts of some herbs such as Vitex Agnus Castus (VAC). Therefore, we investigated the effect of VAC extract on ovariectomized mice after the induction of permanent middle cerebral artery occlusion (PMCAO...

[ 9 ] - Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex

Introduction: Memantine as N-Methyl-D-aspartic acid (NMDA) receptor antagonist is used in some neurological disorders. It has been reported that memantine has modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effect of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording ...