Ayat Kaeidi
Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran|Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
[ 1 ] - CX691 as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’s disease
Objective(s): Growing evidence suggests that dysfunction of the glutamatergic system and α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptors are involved in pathology of Alzheimer’s disease (AD). Because AMPA receptors play a key role in plasticity synaptic regulation, positive modulation of these receptors may rescue the cognitive deficits in the AD. The aim of this study was ...
[ 2 ] - Protective effect of metformin on D-galactose-induced aging model in mice
Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), ...
[ 3 ] - The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence
Objective(s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats. Materials and Methods: For assessing the development of morphine dependence, AMG9810 (0.0...
[ 4 ] - Sumatriptan ameliorates renal injury induced by cisplatin in mice
Objective(s): Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effe...
[ 5 ] - The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study
Background and Objectives: Caraway (Carum carvi) is one of the medicinal plants which is traditionally used for weight loss. The purpose of the present study was to determine the effect of 6 weeks aerobic training and aqueous extract of caraway seed (carum carvi) on expression of CTRP12 gene, body weight changes and subcutaneous adipose tissue in obese male rats. Materials and Methods: In this...
[ 6 ] - The Protective Effect of Carvacrol and Thymol as Main Polyphenolic Compounds of Thyme on Some Biologic Systems in Disease Condition: A Narrative Review
Thyme plant is a member of the mint family that is considered as an aromatic perennial evergreen medical herb. Carvacrol and thymol are known as two important phenolic compounds of thyme plant. Carvacrol and thymol have been identified as antioxidant, anti-oxidative and anti-inflammatory substances. Also, the neuroprotective, hepatoprotective and renoprotective effects of these polyphenolic com...
[ 7 ] - The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study
Background and Objectives: Chronic morphine use leads to structural changes in the brain. Some studies have shown the antioxidant and neuroprotective effects of Epigallocatechin gallate (EGCG) as a main polyphenol of green tea. Therefore, the aim of this study was to investigate the effect of EGCG on working memory in morphine-treated rats. Materials and Methods: In this experimental study, 32...
[ 8 ] - Effect of Troxerotin on permanent cerebral ischemia in male mice
Introduction: Stroke is a neurological disease and one of the leading causes of death all over the world. It is also an important cause of disability in people over age over 65. It may be possible to reduce the incidence of cerebral ischemia using antioxidants, followed by inhibition of oxidative and inflammatory mechanisms. Troxerutin is a natural bioflavonoid with antioxidant and anti-inflamm...
[ 9 ] - Effect of Metformin on Some Cognitive Functions in Old Rats
Introduction: Aging is a complex process and is considered as a risk factor for many diseases such as hypertension, Alzheimer, cancer, depression and anxiety. Recently, it has been shown that metformin, an anti-diabetic drug, has important neurological effects such as preventing memory loss, stroke, anxiety, inflammation and seizures. Therefore, the aim of this study was investigating the effec...
[ 10 ] - Pretreatment effects of metformin on behavioral manifestations of global ischemia/reperfusion injury in rats
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
[ 11 ] - The Oleuropein Effect on Neurotrophic Factor Expression Level in Hippocampal Tissue and Memory Defect Induced by Morphine in Male Rats: An Experimental Study
Background and Objectives: Taking morphine can cause damage to the hippocampus. Oleuropein has a protective effect on brain neurons. The aim of this study was to determine the effect of oleuropein on brain-derived neurotrophic factor (BDNF) protein expression level in hippocampal tissue and memory defect induced by morphine in rats. Materials and Methods: In this experimental study, 40 male Wi...
[ 12 ] - Effect of Ischemic Conditioning on Some Motor and Cognitive Factors in the Ovariectomy-Induced Aged Rats
Introduction: During menopause, which is a part of the aging process in women, the level of sex hormones decreases, which causes problems such as memory impairment and cognitive functions. One of the treatment options for these disorders is hormone therapy, which has several side effects. The present study investigated the effect of remote ischemic conditioning (RIC) technique on memory improve...
[ 13 ] - Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex
Introduction: Memantine as N-Methyl-D-aspartic acid (NMDA) receptor antagonist is used in some neurological disorders. It has been reported that memantine has modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effect of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording ...
[ 14 ] - Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor
Background and Objectives: Coronavirus 2019 (Covid-19) has become a global disease that can affect various organs of the human body. Kidney disorders are the most common disorders in patients with Covid-19. Kidney involvement manifests as proteinuria and acute kidney injury (AKI). This virus can cause acute tubular necrosis, protein leakage in the Bowman's capsule, glomerulopathy, and mitochond...
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