زمانی, محمد
، گروه علوم تشریح، دانشکده پزشکی، دانشگاه علوم پزشکی اصفهان
[ 1 ] - استفاده توأم از اسکوربیک اسید و آگونیست آدنوزین رسپتور A1 بهعنوان درمانی جدید برای ایسکمی قشر مغز- بررسی در مدل حیوانی
Background & Aims : Today stroke is a leading cause of death in the world. Early treatment can reduce the complications of the disease. The aim of this study was to examine the effect of A1 receptor agonists and Neuroprotective effects of ascorbic acid on brain ischemia. Materials & Methods : This study was done on temporal lobe of the brain and performed on eight groups of mice. Ischemia...
[ 2 ] - The effect of AT2 and Mas receptors antagonists on renal hemodynamic and excretory disorders induced by ischemia/reperfusion in male and female rats
Introduction: Renal ischemia-reperfusion (RIR) may disturb renin-angiotensin system components. In this study, the effects of Mas receptor (A779) and AT2 receptor (PD123319) antagonists were examined in RIR rats. Methods: Total 60 male and female Wistar rats were assigned into 10 groups (n=6 in each group), including sham-operated group, RIR groups treated with the vehicle, A779, PD123319, ...
[ 3 ] - Renin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
[ 4 ] - The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence
Objective(s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats. Materials and Methods: For assessing the development of morphine dependence, AMG9810 (0.0...
[ 5 ] - Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice
Objective(s): Ceftriaxone (Cef), a beta-lactam antibiotic, is accompanied by antioxidant and anti-inflammatory properties. It has been shown that Cef has beneficial effects on Alzheimer’s disease. In the current investigation, the effect of Cef in a mice model of aging was investigated. Materials and Methods: Forty male mice were equally...
[ 6 ] - The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study
Background and Objectives: Chronic morphine use leads to structural changes in the brain. Some studies have shown the antioxidant and neuroprotective effects of Epigallocatechin gallate (EGCG) as a main polyphenol of green tea. Therefore, the aim of this study was to investigate the effect of EGCG on working memory in morphine-treated rats. Materials and Methods: In this experimental study, 32...
[ 7 ] - Effect of Troxerotin on permanent cerebral ischemia in male mice
Introduction: Stroke is a neurological disease and one of the leading causes of death all over the world. It is also an important cause of disability in people over age over 65. It may be possible to reduce the incidence of cerebral ischemia using antioxidants, followed by inhibition of oxidative and inflammatory mechanisms. Troxerutin is a natural bioflavonoid with antioxidant and anti-inflamm...
[ 8 ] - The Oleuropein Effect on Neurotrophic Factor Expression Level in Hippocampal Tissue and Memory Defect Induced by Morphine in Male Rats: An Experimental Study
Background and Objectives: Taking morphine can cause damage to the hippocampus. Oleuropein has a protective effect on brain neurons. The aim of this study was to determine the effect of oleuropein on brain-derived neurotrophic factor (BDNF) protein expression level in hippocampal tissue and memory defect induced by morphine in rats. Materials and Methods: In this experimental study, 40 male Wi...
[ 9 ] - Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor
Background and Objectives: Coronavirus 2019 (Covid-19) has become a global disease that can affect various organs of the human body. Kidney disorders are the most common disorders in patients with Covid-19. Kidney involvement manifests as proteinuria and acute kidney injury (AKI). This virus can cause acute tubular necrosis, protein leakage in the Bowman's capsule, glomerulopathy, and mitochond...
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