Iman Fatemi
Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran|Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
[ 1 ] - CX691 as an AMPA receptor positive modulator, improves the learning and memory in a rat model of Alzheimer’s disease
Objective(s): Growing evidence suggests that dysfunction of the glutamatergic system and α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptors are involved in pathology of Alzheimer’s disease (AD). Because AMPA receptors play a key role in plasticity synaptic regulation, positive modulation of these receptors may rescue the cognitive deficits in the AD. The aim of this study was ...
[ 2 ] - Protective effect of metformin on D-galactose-induced aging model in mice
Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), ...
[ 3 ] - اثر متفورمین بر یادگیری لمسی و رفتار شبه اضطرابی در موش سوری اوارکتومی شده
Introduction: Estrogen regulates many processes in the brain such as synaptic formation, learning, and memory. Empirical evidence shows that there is a correlation among menopause, memory impairment, and anxiety due to Estrogen deficiency. In this study, we tested the effect of Metformin (Met) with antioxidant effect, which can improve the impairment of tactile learning and anxiety-like behavio...
[ 4 ] - بررسی اثر متفورمین بر روی برخی شاخصهای رفتاری در موش سوری اوارکتومی شده
Introduction: Aging process is inevitable, which increases the risk of illness and death in people. Menopause occurs as a part of the aging process. The aim of this study was to evaluate the effect of metformin (Met) on muscle strength, anxiety and memory in ovariectomized mice Methods: Thiswas an experimental study. 96 female mice (Age 6 months) (20-25 g) were randomly divided into sex group...
[ 5 ] - The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence
Objective(s): This study investigated the role of locus coeruleus (LC) nucleus TRPV1 receptors (TRPV1r) in the expression and development of morphine physical dependence by intra-LC administration of AMG9810 (selective TRPV1r antagonist) in male Wistar rats. Materials and Methods: For assessing the development of morphine dependence, AMG9810 (0.0...
[ 6 ] - Protective effects of Vitex agnus-castus in ovariectomy mice following permanent middle cerebral artery occlusion
Objective(s): Previous studies have indicated that phytoestrogens induce estrogenic as well as anti-inflammatory effects, and they are found in high abundance in the extracts of some herbs such as Vitex Agnus Castus (VAC). Therefore, we investigated the effect of VAC extract on ovariectomized mice after the induction of permanent middle cerebral artery occlusion (PMCAO...
[ 7 ] - Sumatriptan ameliorates renal injury induced by cisplatin in mice
Objective(s): Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effe...
[ 8 ] - The Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study
Background and Objectives: Chronic morphine use leads to structural changes in the brain. Some studies have shown the antioxidant and neuroprotective effects of Epigallocatechin gallate (EGCG) as a main polyphenol of green tea. Therefore, the aim of this study was to investigate the effect of EGCG on working memory in morphine-treated rats. Materials and Methods: In this experimental study, 32...
[ 9 ] - Pretreatment effects of metformin on behavioral manifestations of global ischemia/reperfusion injury in rats
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats. Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four g...
[ 10 ] - Effect of Ischemic Conditioning on Some Motor and Cognitive Factors in the Ovariectomy-Induced Aged Rats
Introduction: During menopause, which is a part of the aging process in women, the level of sex hormones decreases, which causes problems such as memory impairment and cognitive functions. One of the treatment options for these disorders is hormone therapy, which has several side effects. The present study investigated the effect of remote ischemic conditioning (RIC) technique on memory improve...
[ 11 ] - Microscopic examination of the effect of bromelain on the healing of tooth extraction sockets in an animal model
Background and Aims: Bromelain is a substance derived from pineapple and has antioxidant, anti-inflammatory, and analgesic effects. This study aimed to investigate the effect of bromelain on the healing of tooth extraction sockets in an animal model. Materials and Methods: This experimental study was performed on 24 male rats. After anesthesia, the first maxillary molar tooth was extracted wit...
[ 12 ] - Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex
Introduction: Memantine as N-Methyl-D-aspartic acid (NMDA) receptor antagonist is used in some neurological disorders. It has been reported that memantine has modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effect of memantine on electrophysiological properties of barrel cortex neurons in male rats. Methods: Single unit recording ...
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