نتایج جستجو برای: export opportunity

تعداد نتایج: 116203  

In the current world, export development is not limited to increasing foreign exchange earnings through exports of goods and services, but also plays a more important role as a growth strategy and even economic development in the world. Therefore, how to become a successful exporter is becoming more and more important. The main objective of this study was to study the effect of entrepreneurial ...

Journal: :Molecular biology of the cell 1999
K S Ullman S Shah M A Powers D J Forbes

The fundamental process of nucleocytoplasmic transport takes place through the nuclear pore. Peripheral pore structures are presumably poised to interact with transport receptors and their cargo as these receptor complexes first encounter the pore. One such peripheral structure likely to play an important role in nuclear export is the basket structure located on the nuclear side of the pore. At...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
B R Cullen

A lthough the mechanisms regulating the nuclear export of eukaryotic mRNAs remain poorly understood, it has been known for some time that premRNAs, i.e., mRNAs that retain functional splice sites, are actively retained in the nucleus by what are termed splicing commitment factors (1, 2). The subsequent nuclear export of mature mRNAs therefore could be perceived as being largely caused by the re...

2016
Tohru Minamino Yusuke V. Morimoto Noritaka Hara Phillip D. Aldridge Keiichi Namba

The bacterial flagellar type III export apparatus utilizes ATP and proton motive force (PMF) to transport flagellar proteins to the distal end of the growing flagellar structure for self-assembly. The transmembrane export gate complex is a H+-protein antiporter, of which activity is greatly augmented by an associated cytoplasmic ATPase complex. Here, we report that the export gate complex can u...

Journal: :Current Biology 2001
Ben E. Black James M. Holaska Fraydoon Rastinejad Bryce M. Paschal

BACKGROUND The nuclear receptor superfamily of transcription factors directs gene expression through DNA sequence-specific interactions with target genes. Nuclear import of these receptors involves recognition of a nuclear localization signal (NLS) by importins, which mediate translocation into the nucleus. Nuclear receptors lack a leucine-rich nuclear export signal (NES), and export is insensi...

Journal: :The Journal of Cell Biology 2001
Wilma Hofmann Beate Reichart Andrea Ewald Eleonora Müller Iris Schmitt Roland H. Stauber Friedrich Lottspeich Brigitte M. Jockusch Ulrich Scheer Joachim Hauber Marie-Christine Dabauvalle

Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated by the export receptor CRM1/exportin1. However, additional protein factors interacting with leucine-rich NESs have been described. Here, we investigate human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export and Mason-Pfizer monkey virus (MPMV) constitutive transport element (CTE)-mediat...

Journal: :The EMBO journal 1997
A E Pasquinelli R K Ernst E Lund C Grimm M L Zapp D Rekosh M L Hammarskjöld J E Dahlberg

The constitutive transport elements (CTEs) of type D retroviruses are cis-acting elements that promote nuclear export of incompletely spliced mRNAs. Unlike the Rev response element (RRE) of human immunodeficiency virus type 1 (HIV-1), CTEs depend entirely on factors encoded by the host cell genome. We show that an RNA comprised almost entirely of the CTE of Mason-Pfizer monkey virus (CTE RNA) i...

Journal: :The Journal of Cell Biology 2001
James M. Holaska Ben E. Black Dona C. Love John A. Hanover John Leszyk Bryce M. Paschal

In previous work, we used a permeabilized cell assay that reconstitutes nuclear export of protein kinase inhibitor (PKI) to show that cytosol contains an export activity that is distinct from Crm1 (Holaska, J.M., and B.M. Paschal. 1995. Proc. Natl. Acad. Sci. USA. 95: 14739-14744). Here, we describe the purification and characterization of the activity as calreticulin (CRT), a protein previousl...

Journal: :PloS one 2016
Bettina Neumann Haijia Wu Alexandra Hackmann Heike Krebber

The DEAD-box RNA-helicase Dbp5/Rat8 is known for its function in nuclear mRNA export, where it displaces the export receptor Mex67 from the mRNA at the cytoplasmic side of the nuclear pore complex (NPC). Here we show that Dbp5 is also required for the nuclear export of both pre-ribosomal subunits. Yeast temperature-sensitive dbp5 mutants accumulate both ribosomal particles in their nuclei. Furt...

Journal: :Journal of cell science 2004
Joel G Turner Roxanne Engel Jennifer A Derderian Richard Jove Daniel M Sullivan

Resistance to chemotherapeutic drugs is a major obstacle in the treatment of leukemia and multiple myeloma. We have previously found that myeloma and leukemic cells in transition from low-density log phase conditions to high-density plateau phase conditions export substantial amounts of endogenous topoisomerase II alpha from the nucleus to the cytoplasm. In order for topoisomerase-targeted chem...

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