In the title compound, C(23)H(27)F(3)N(2)OS(+)·2Cl(-), the piperazinediium ring adopts a chair conformation. The dihedral angle between the two outer aromatic rings of the 9H-thioxanthene unit is 40.35 (18)°. The F atoms in the trifluoro-methyl group are disordered over two sets of sites with occupancies of 0.803 (6) and 0.197 (6). In the crystal, mol-ecules are connected by N-H⋯Cl, O-H⋯Cl C-H⋯...

CL/Fpop and V/Fpop represent the typical oral clearance value and apparent volume of distribution value for the adult population, and weightpop represents a typical weight for the adult population. CL/F for an infant was also allowed to mature to an allometrically scaled adult value according to age (months) to reach the population value CL/Fpop, hence kmat is a first-order rate constant that d...

The aim of the current study was to evaluate the accuracy of allometric scaling methods for drugs metabolized by UDP-glucuronosyltransferases (UGTs), such as ketoprofen, imipramine, lorazepam, levofloxacin, zidovudine, diclofenac, furosemide, raloxifene, gemfibrozil, mycophenolic acid, indomethacin, and telmisartan. Human plasma clearance (CL) predictions were conducted from preclinical in vivo...

Seven Zn(II) coordination complexes with 5-halonicotinic acids (HL-X, X = F, Cl, or Br) have been synthesized with different synthetic approaches, including layer diffusion or stirring method in an ambient environment and solvothermal synthesis at 100 °C. Assembly of HL-F with Zn(II) under different conditions will yield the same 2D network of [Zn(L-F)2]n (1). Interestingly, three distinct comp...

Objective(s) The purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (VPA) in bipolar patients in comparison with those of epileptic patients. Materials and Methods Ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. Blood samples were...

Voltage-clamp techniques were used to study the membrane currents elicited by follicle stimulating hormone (FSH) and acetylcholine (ACh) in follicle-enclosed oocytes of Xenopus laevis (follicles). Both agonists caused complex responses that were more evident when the follicles were in hypotonic Ringer solution (HR; 190.4 mosM). In this medium, currents activated by FSH regularly showed three ph...

The title compound, (C(44)H(38)P(2))[AuCl(C(6)F(5))](2)·2CH(2)Cl(2), crystallizes with a twofold rotation axis through the central benzene ring in the bis-phospho-nium dication. In the crystal, the dications and anions are ordered into columns running parallel to the c axis by contacts of the pro-ylidic CH(2) groups with the Cl atom of one and an ortho-F atom of another anion. The space between...

in the present study, 45 rainwater samples were collected from february to december 2012 on event basis in east bokaro coal mining environment. physico-chemical and major ionic compositions of rainwater samples as well as water soluble major ion composition were analyzed to employ principle component analysis for source identification. the average ph value was recorded 6.1 and varied from 5.1 t...