The technique of experimental design is used on an ethylene polymerization process model in order to map the feasible optimal region as preliminary information for process optimization. Through the use of this statistical tool, together with a detailed deterministic model validated with industrial data, it is possible to identify the most relevant variables to be considered as degrees of freedo...

State University of New York at Stony Brook 2A two-level factorial design can be uniquely represented by a polynomial indicator function. Therefore, properties of factorial designs can be studied through their indicator functions. This paper shows that indicator function is an effective tool in studying two-level factorial designs. Indicator function is used to generalize aberration criterion o...

Loss becomes a problem in the hair that causes baldness. Biotin is vitamin nourishes and prevents loss. which formulated microemulsion tends to be transparent, has low viscosity high solubility. Formula optimization was carried out determine concentration of span 80, tween PEG 400 biotin tonic. The research conducted on an experimental basis using factorial design method with 3 factors, namely ...

recently full factorial design approach has been used to assess the recycling potential of a given waste. the objective of this study is to identify the significant factors and interactions involved in maximizing compressive strength of concrete when chromium waste is used as admixture. in this respect, experimental factors at two levels, which are admixture type (chromite/ chromite+ superplas...

In order to achieve prolong corneal contact time of norfloxacin(NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

In order to achieve prolong corneal contact time of norfloxacin(NFX) for treatment of extra ocular diseases, a pH triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. NFX loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

Two-level factorial and fractional factorial designs have played a prominent role in the theory and practice of experimental design. Though commonly used in industrial experiments to identify the significant effects, it is often undesirable to perform the trials of a factorial design (or, fractional factorial design) in a completely random order. Instead, restrictions are imposed on the randomi...

Factorial designs for clinical trials are often encountered in medical, dental, and orthodontic research. Factorial designs assess two or more interventions simultaneously and the main advantage of this design is its efficiency in terms of sample size as more than one intervention may be assessed on the same participants. However, the factorial design is efficient only under the assumption of n...

A new approach using microtiter plate cultivation with on-line measurement of dissolved oxygen (DO) was applied for medium optimization of mammalian cell culture. Applying dynamic liquid phase balance, oxygen uptake rates were calculated from the DO level and used as an indicator for culture viability. The developed method was successfully applied to optimization of the concentration of glucose...