In 1941 Gregg provided the first evidence that rubella virus (family Togaviridae, genus Rubivirus) causes human congenital defects (1). Although rubella virus infection usually causes a mild disease comprising fever and rash, rubella epidemics have been associated with congenital defects in children of women who became infected during their first trimester of pregnancy (2). The risk of in utero...

Background and Aims: New advances in the use of cell-free fetal DNA (cffDNA) in maternal plasma of pregnant women has provided the possibility of applying cffDNA in prenatal diagnosis as a non-invasive method. One of the applications of prenatal diagnosis is fetal gender determination. Early prenatal determination of fetal sex is required for pregnant women at risk of X-linked and some endocrin...

Introdução: a Síndrome Alcoólica Fetal é caracterizada por um conjunto de alterações cognitivas, comportamentais, sistêmicas e orofaciais em crianças nascidas mulheres que fazem uso álcool durante gestação Objetivo: reconhecimento das bucais presentes na alcoólica fetal, fim orientar o cirurgião dentista no seu diagnóstico, assim como ações busquem melhorias para saúde geral bucal seus portador...

"you may take notes for twenty years, from morning to night at the bedside of the sick, upon the diseases of the viscera, and all will be to you only a confusion of symptoms,-a train of incoherent phenomena. Open a few bodies, this obscurity will disappear." Bichat (c 1800)' Rituals related to the disposal of the dead date back to prehistoric times. They arose from religious beliefs and from a ...

the first step in the prenatal diagnosis of x-linked genetic disorders is determining fetus gender. current invasive methods to obtain the dna source of the fetus instead of its miscarriage risk, has harmful stress for high risk pregnancies. cell free fetal dna (cffdna) circulating in the maternal blood, has now become a useful source of noninvasive prenatal diagnosis. considering limitation of...

background: there are many parameters that modulate the severity of sickle cell anemia. fetal hemoglobin (hb f) is one of these major variables. however, its effect is clinically inconsistent. we conducted a descriptive study to assess the influence of hb f on clinical events and hematological variables in patients with sickle cell anemia. methods: 151 patients with sickle cell anemia with a st...

background: free fetal dna (ffd) in maternal plasma/serum has increasingly become the source of fetal material for diagnostic purposes in recent years. this source of fetal material can be used for sex determination. rh typing paternally inherited sequences and compound heterozygosity. reports on the lack of consistent pcr amplification of y-chromosome sequences of ffd in maternal plasma/serum ...

backgroundpregnancy and delivery are among the most stressful events in women’s life . breech presentation is defined as a fetus in a longitudinal lie with the buttocks or feet closest to the cervix. this occurs in 3-4% of all deliveries.the risk for perinatal mortality was 1 in 300 for planned breech deliveries.some conventional non-surgical therapies for breech presentation are available. acu...

background: when we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus. methods: six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. fetal lambs were divided proportionally into 2 groups, namely group 1, diaphragmatic hernia and tracheal ligation (tl group), and group 2, diaphragmatic hernia only (nl gr...