Novel therapeutics are desperately needed for the difficult-to-treat and very lethal malignancy known as hepatocellular carcinoma (HCC). The first drug now authorized treatment of individuals with advanced HCC is sorafenib. To find novel Vascular Endothelial Growth Factor Receptor Inhibitors prospective candidate HCC, an in-silico technique was used in this case. Docking investigations were con...

OBJECTIVE To assess the occurrence of an aggregate risk to cardiometabolic and musculoskeletal health of Brazilian adolescents in the period 2008/09 and 2013/14 and to identify whether there are differences in risk between the genders and in these periods. METHODS This was a trend epidemiological study with a quantitative approach, consisting of a voluntary sample of adolescents from 16 Brazi...

Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating exercise-induced structural and functional changes in the hippocampus. Recently, also platelet derived growth factor-C (PDGF-C) has been shown to promote blood vessel growth and neuronal survival. Moreover, reductions...

background & aim: maintaining and improving the work ability are important social goals, which challenge the health care and rehabilitation systems as well as health providers. the physical and mental health status affect the work ability. regarding this, the current study aimed to investigate the effect of aerobic training on the work ability of the midwives in the health care centers of mashh...

to evaluate the influence of core thickness and fabrication stages on the marginal accuracy of ips e.max press crowns.twenty ips e.max press crowns, 1.5mm thick, were fabricated on metal dies. the crowns had two different core thicknesses, 0.8mm for group a and 1mm for group b, ten for each group. marginal gap was measured after each stage of core fabrication, veneering and glaze firing. the sp...

the aim of this study was to investigate the effect of external intervention factor (types of music) on physical fitness factors in adolescent boys. 30 adolescent boys (9-12 years old, msd height, weight and bmi: 133.82.40 cm, 35.62.97 kg, and 19.91.21 kg/cm2), were selected and performed the tests in three stages (fast music, slow music, control) with counter balance method. in each stage, the...

researchers demonstrate that individuals in different levels of physical activity have different motivations for sport activity. this study was designed to examine how motivations can discriminate three physical activity levels (inactive, active, sustained maintainers) according to self-determination theory. 159 zanjan university staff (mean age: 33 years old) completed exercise motivation inve...

This paper presents a pilot research of approaches taken by European Union (EU) Member States (MSs) in the emergency response to COVID-19 crisis pre-tertiary education. It includes multi-case study four MSs, examining their education systems’ digital readiness and “fitness for change”, as well decision-making practices. We use Cynefin framework decision contexts explore different paths shifting...

BACKGROUND Physical function declines up to 4% per year after the age of 65. High-velocity training is important for maintaining muscular power and ultimately, physical function; however, whether performing high-velocity training without external resistance increases functional fitness among older adults remains unclear. OBJECTIVE The purpose of this investigation was to evaluate loaded and u...