Background Fertility preservation is an important part of scientific study in the field of reproductive medicine. Ovarian cryopreservation and in vitro follicles culture provide option for fertility conservation in older women or cancer patients. Basic fibroblast growth factor (bFGF) or FGF-2, is member of fibroblast growth factors family which play critical roles in cell migration proliferatio...

This study evaluated the levels of c-kit mRNA in goat follicles and the effects of kit ligand (KL) on the in vitro development of cultured preantral follicles. Preantral follicles isolated from goat ovarian cortex were cultured for 18 days in α-MEM(+) supplemented with KL (0, 50 or 100 ng/mL) in the absence or presence of follicle stimulating hormone (FSH). Real-time PCR showed that c-kit mRNA ...

Background Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle. This study aimed to clarify the mechanisms underlying these phenomena. Methods The literature was reviewed, including that published by the authors. Main findi...

background: based on classical two-cell, two-gonadotropin theory, in the follicle, follicle-stimulating hormone (fsh) and luteinizing hormone (lh) put on their main effects on the granulosa and theca cells. lh is essential for androgens production. androgens are used for estradiol production by granulosa cells. profound suppression of lh concentrations in some normogonadotropic patients can cau...

The purification and action sites of a follicle stimulating hormone (FSH) inhibitor obtained from bovine follicular fluid were examined. Bovine follicular fluid was salted out with ammonium sulfate as a concentration of 14.5 to 18.5%, and the salted out fraction was separated into two peaks by Sephadex G-200 column chromatography. The second peak, detectable as a single band by polyacrylamide g...

when concentrations of luteinising hormone are high throughout the follicular phase, as in some women with polycystic ovaries, the hormone penetrates the follicle and allows the oocyte to mature prematurely, resulting in ovulation of an oocyte that is physiologically "aged." Such oocytes are unlikely to be fertilised or will tend to produce embryos that implant poorly and therefore abort. Data ...

121 women with polycystic ovarian syndrome and clomiphene citrate resistance underwent laparoscopic ovarian cautery, 63 patients were type i or typical pcos with ovarian volume >8ml and 58 patients were type ii pcos with ovarian volume <8ml. serum concentrations of luteinizing hormone (lh), follicular stimulating hormone (fsh), prolactin (prl), testosterone (t), and dehydroepiandrosterone sulfa...

background: chlorpromazine (cpz), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. the current study evaluates the effect of cpz-induced hyperprolactinemia on ovarian follicular growth, gonadotropins, and alteration of ovarian source hormones. materials and methods: in this experimental study, animals were divided into four grou...

Menopause, represents the end of woman’s reproductive life, is defined as the changeless stoppage of ovarian follicular activity and the menstrual cycle. This physiological process is characterized by alterations related with sex hormones and stepwise decrease of estrogen secretion. Thus, estradiol ranging from 5 to 25 pg/mL, while rising titers of gonadotrophins, so the levels of follicle stim...