In a large family with the fragile X syndrome, we performed linkage investigations with six probes, detecting RFLPs at both sides of the fragile site Xq27. The nearest flanking markers were cX55.7 (DXS105) on the centromeric side (theta = 0.04, lod 5.0) and St14 (DXS52) on the telomeric side (theta = 0.08, lod 4.0). Non-penetrance could be shown by the presence of the grandpaternal X chromosome...

The scattering by a pair of spatially disjoint local regions of complex (multiscale) stiiness heterogeneity in an unbounded thin linearly elastic plate, is investigated. Issues of the mutual interaction of the spatially disjoint scatterers and its manifestation within a homogenized, or eeective, formulation governing large scale response elds, are the focus. It is shown analytically and numeric...

the modulation response, relative intensity noise and frequency noise characteristics of qd lasers are investigated theoretically, in presence of an additional optical pumping. it is revealed that the modulation response of qd laser enhances under additional optical beam. by small signal analysis of the carriers' and photons' rates, it is proposed that by injecting excess carriers to ...

BACKGROUND The differential diagnosis of thyroid nodules is very important in deciding the treatment modality and the fine needle aspiration is the best diagnostic method. But, there are some limitations in use because of inadequate test materials and difficulty in interpreting. According to the study of oncogene and tumor suppressor gene about the origin of thyroid tumor, expression of Fra-1, ...

Although a replication-competent retrovirus that carries junD has no transforming activity in chicken embryo fibroblasts, we have isolated mutant viruses that have spontaneously acquired transforming activity. The molecularly cloned junD genes of three such mutant viruses (T1, T2, and T3) were shown to be responsible for the cellular transformation. DNA sequence analysis indicated that a specif...

This paper provides onvergen e analysis for maximum likelihood estimation of the parameters des ribing a parti ular multi-s ale pro ess known as fra tional Brownian motion. We on entrate on s hemes that `pre-whiten' the available noise orrupted data via the Fast Wavelet Transform and show that su h s hemes are strongly onsistent and asymptoti ally eÆ ient. We also analyse the rate of onvergen e...

The nonlinear system becomes an area with numerous investigations over the past decades. The conventional modal analysis could not be  applied on nonlinear continuous system which makes it impossible to construct the reduced order models and obtain system response based on limited number of measurement points. Nonlinear normal modes provide a useful tool for extending modal analysis to nonlinea...

Activator protein 1 (AP-1) is a transcriptional factor composed of the dimeric members of bZIP proteins, which are frequently deregulated in human cancer cells. In this study, we aimed to identify an oncogenic AP-1 dimer critical for the proliferation of neuroblastoma cells and to investigate whether histone deacetylase inhibitors (HDACIs), a new generation of anticancer agents, could target th...