A 16-year-old girl with advanced cirrhosis and severe alpha 1-antitrypsin deficiency of the homozygous Pi ZZ phenotype was treated by orthotopic liver transplantation. After replacement of the liver with a homograft from a donor with the normal Pi MM phenotype, the alpha 1-antitrypsin concentration in the recipient's serum rose to normal; it had the Pi MM phenotype. Two and a third years later,...

Wheadey, D. J., Prusty, S., and Ross, D. N. (1974). Thorax, 29, 617-623. Reconstruction of right ventricular outflow with a valved homograft conduit. Since 1966 a conduit of homograft ascending aorta with its valve has been used for reconstruction of the right ventricular outflow. This technique has been applied to 123 operations for pulmonary autograft replacement of the aortic valve, 48 opera...

We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart valve 3-dimensionally. Based on this stereolithographic model, a silicone va...

Nineteen male recipients of renal homografts were responsible for 23 pregnancies, resulting so far in 19 live births and one abortion; three additional wives have not yet been delivered of infants. Eighteen of the 19 infants were normal; the abnormal infant had a myelomeningocele and other anom.alies. Eight female recipients have become pregnant ten times. Two of the pregnancies were terminated...

A 54-year-old male clerical worker was admitted to the unit on May 27, 1971, with intractable pulmonary oedema secondary to aortic regurgitation associated with bacterial endocarditis. Five years previously he had undergone a homograft valve replacement for calcine aortic stenosis. His treatment on admission consisted of cephaloridine 1 g 6-hourly intravenously, digoxin 0.25 mg 8hourly, frusemi...

The cardiovascular effects of an intravenous infusion of adrenaline (10 mug./min.) and isoprenaline (0.75 mug./min.) have been compared in two groups of six patients in the early post-operative period following aortic valvar homograft replacement. These doses were chosen to produce obvious haemodynamic effects without precipitating dysrhythmias. Though both drugs have been shown to improve the ...

necropsy. The normal aortic valve echocardiogram is described and evidence is given that the anteriorly visualized cusp echoes arefrom the right coronary but those which are posteriorly visualized may befrom the non-coronary or the left coronary cusp. The ultrasound patterns in aortic stenosis, aortic regurgitation, and mixed aortic valve disease are described. In each case the aortic root diam...

In this report, attention will be focused upon new or contraversial aspects of homotransplantation of the liver. Although interest in liver transplantation dates from Welch's first reports almost 10 years ago (1, 2), there was at first little justification from laboratory experimentation for hope that such a procedure had a therapeutic clinical potential. In the recent past, the outlook has mar...