نتایج جستجو برای: fshr
تعداد نتایج: 474 فیلتر نتایج به سال:
Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm birth is a disorder of profound global health significance. The signals initiating parturition in humans have remained elusive, due to divergence in physiological mechanisms between humans and model organisms typically studied. Because of relatively large human head size and narrow bir...
Single GATA-6 (G6(gcko)), GATA-4 (G4(gcko)), and double GATA-4/6 (G4/6(gcko)) granulosa cell-specific knockout mice were generated to further investigate the role of GATA transcription factors in ovarian function in vivo. No reproductive defects were found in G6(gcko) animals. G4(gcko) animals were subfertile as indicated by the reduced number of pups per litter and the release of significantly...
Background: Atractylodes macrocephala Koidz (AMK) is a tonic herb widely prescribed in most Asian countries, which has been clinically used as the dominant herb in most of the Chinese medicinal formula of treating polycystic ovarian syndrome (PCOS). Objective: To explore the effects of a polar extract of AMK (EAMK) in a hyperandrogenic rat model of PCOS induced by testosterone propionate. Mater...
BACKGROUND Poor ovarian response phenomenon has been observed in some of the in vitro fertilization-embryo transfer patients. Some investigations found that follicle stimulating hormone receptor ( FSHR ) gene plays a role in the process, but no direct evidence shows the correlation between genotypes of FSHR and ovarian response. OBJECTIVE Exploring the molecular mechanism behind the mutation ...
هدف از این مطالعه شناسایی چند شکلی در ژن گیرنده هورمون محرک فولیکولی ((fshr و زیر واحد بتای هورمون محرک فولیکولی (fsh?) و رابطه آن ها با صفت وزن بدن در سنین مختلف و نرخ زایش در گوسفندان نژاد ایران بلک، آرمان و بلوچی بوده است. برای این منظور در مجموع 150 نمونه خون به طور تصادفی از گوسفندان سه نژاد مذکور در ایستگاه اصلاح نژاد واقع در عباس آباد مشهد جمع آوری شد. دی ان ای هر یک از نمونه ها به روش ن...
Premature ovarian failure (POF) is a heterogeneous disorder, defined as menopause under age 40 years. The prevalence is 1%; POF before age 30 years is much less common. Chromosomal causes have long been recognized - visible deletions of the X chromosome, 45,X/46,XX mosaicism, and autosomal rearrangements (balanced translocations). Toxins or iatrogenic causes (e.g., chemotherapeutic agents) are ...
CONTEXT Previous studies showed that nerve growth factor (NGF) induces the expression of functional FSH receptors (FSHR) in preantral follicles of the developing rat ovary. OBJECTIVE The objective of this study was to determine whether NGF can affect granulosa cell (GC) function in human periovulatory follicles using intact human ovaries and isolated human GCs. PATIENTS AND INTERVENTIONS Hu...
BACKGROUD Ovarian transplantation is a useful method for preserving the fertility of young women with cancer who undergo radiotherapy and chemotherapy. Follicle-stimulating hormone (FSH) is use to protect transplanted ovarian tissues from ischemia injury through promoting revascularization after transplantation, but the side effect of high level FSH is ovarian overstimulation leading to substan...
Ovarian Hyperstimulation Syndrome (OHSS) is usually iatrogenic and potentially life-threatening complication of ovulation induction [1]. It has been categorized into three types according to the proposed mechanisms; type 1 corresponds to the mutated FSH receptor (FSHr) genes; type 2 corresponds to the spontaneous OHSS secondary to high levels of human chorionic gonadotropin (HCG), which is the ...
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