materials and methods genotyping of the mia3 gene was undertaken using taqman real-time pcr in all subjects. anthropometric and biochemical features, including hdl, ldl, and tg were assessed in all subjects. results the cad patients had significantly (p < 0.05) higher bmi and significantly higher levels of tg, ldl, sbp, and dbp, while the level of hdl was lower compared to that of the control g...

BACKGROUND Resistin is a circulating adipokine with insulin-antagonizing effects. The aim of this study was to investigate the relationship between the single nucleotide polymorphism (SNP) -420C > G in the resistin gene with serum resistin levels, insulin resistance, and risk of gestational diabetes (GDM) in Iranian population. METHOD 75 GDM patients and 70 healthy pregnant women were enrolle...

BACKGROUND There are contrary results about the role of CACNA1A gene in the causation of common migraine in different populations. However, migraine may be genetically heterogeneous and more studies in different families and populations are required for a definite conclusion. The aim of this study was to surveyed leukocyte genomic DNA mutation of CACNA1A in Iranian migraine patients with [MA] a...

Callipyge (CLPG) is a candidate gene with significant effect on meat quality and growth in sheep. The aim of this study was to investigate the polymorphism CLPG Akkaraman breed. In study, DNAs obtained from blood samples 50 sheep used as material. CLPG/Faq1 examined all individuals using method PCR-RFLP. Only A allele AA genotype were detected after PCR-RFLP procedure. This first which investig...

background multiple sclerosis (ms) is an autoimmune disease that affects the central nervous system (cns). ms is one of the most common cause of neurological impairment at a young age with a complex etiology. the forkhead/winged helix (foxp3) gene encodes a transcription factor that plays an important role in the working and progress of regulatory t cells. loss of the foxp3 function impairs the...

Cysteine-cysteine chemokine ligand 5 (CCL5) with immunoregulatory and inflammatory activities has an important role in granuloma formations that activates and stimulates T-cells and macrophages. Cysteine-cysteine chemokine receptor 5 (CCR5) is a chemokine receptor, which is important for migration of immune cells to site of infection. In the present study we investigated the possible associatio...

introduction the accumulation of improperly folded forms of host-encoded cellular prion protein (prpc) in the central nervous system (cns) lead to a fatal neurodegenerative disease in sheep and goats, namely scrapie. the application of genetic breeding programs to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food...

BACKGROUND Adiponectin is an adipokine with insulin-sensitizing effects. We investigated the relationship between the single nucleotide polymorphism (SNP) +45 T > G ( rs 2241766 ;Gly15Gly) in the adiponectin gene, serum adiponectin levels, insulin resistance and risk of gestational diabetes (GDM) in Iranian population. METHODS 65 GDM patients and 70 healthy pregnant women were enrolled in thi...

background: antigen b (agb) is frequently used for immuno-diagnosis of hu-man cystic echinococcosis (ce). echinococcus granulosus agbs show a high degree of genetic variability in different hosts or in different ce endemic areas. the present study aimed to evaluate the genetic polymorphisms of encoding antigen b2 gene (agb2) among different iranian isolates of e. granulosus. methods: a total of...