interferon gamma (ifn-g) is a cytokine produced by activated t lymphocytes and natural killer cells. it plays an important role in innate and adaptive immunity. ifn-g gene is polymorphic and its haplotype has been associated with resistance to nematode infestations which are the most important parasites of domestic sheep worldwide. to evaluate ifn-g polymorphism in iranian shaul sheep populatio...

Several studies have focused on polymorphisms of major histocompatibility complex (MHC) in sheep, Ovar-MHC. This molecule plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. The best-characterized genetic control of disease resistance and immune response in animals is associated with MHC. Numerous molecular genetic investigations have been und...

several studies have focused on polymorphisms of major histocompatibility complex (mhc) in sheep, ovar-mhc. this molecule plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. the best-characterized genetic control of disease resistance and immune response in animals is associated with mhc. numerous molecular genetic investigations have been und...

the human leukocyte antigen (hla)-g molecule is expressed in cytotrophoblast cells, adult thymic epithelial cells, erythroblasts, pancreatic islets and mesenchymal stem  cells. although, hla-g expression in allotransplanted patients is correlated with a better allograft acceptance, it is associated with an advanced grade of the tumor in cancer. in addition to the role on the immune system, hla-...

Genetic polymorphism G6721T (rs.7003908) in gene encoding DNA-dependent protein kinase (DNA-PKcs, encoded by the XRCC7 gene) has been defined. In order to get more insight into the genetic structure of Iranian population the present study was carried out on Iranian Persian population living in Shiraz (Fars province, southwest Iran). The total study subjects consisted of 935 (195 males, 740 fema...

BACKGROUND A functional polymorphism in the uncoupling protein 2 (UCP2) gene promoter has been associated with obesity and type 2 diabetes (T2D) in some populations. The impact of UCP2 polymorphisms on diabetes and obesity is still under debate. Contradictory results have been reported in different populations world-wide. To clarify the contribution of the UCP2 gene -866 G/A polymorphism in the...

Background: Breast cancer is one of the most common cancers among women worldwide. Tumor protein 53 (TP53) and its regulator the mouse double murine 2 (MDM2) have important roles in tumorigenesis by playing key roles in cell division and response to DNA damage. MDM2 SNP309 T>G (rs2279744) polymorphism in the promoter region of MDM2 gene can cause dysfunction and inactivation of TP53 which promo...

Association of genetic polymorphism in the calpastatin (CAST) gene with average daily gain was examined in Iranian purebred Kurdi sheep. The genotypes for CAST were determined by the PCR-SSCP method. Blood samples were collected from 84 purebred Kurdi sheep belonging to the Kurdi Breeding Station located in the Khorasan province, north-east of Iran. Extraction of genomic DNA was based on the Gu...

association of genetic polymorphism in the calpastatin (cast) gene with average daily gain was examined in iranian purebred kurdi sheep. the genotypes for cast were determined by the pcr-sscp method. blood samples were collected from 84 purebred kurdi sheep belonging to the kurdi breeding station located in the khorasan province, north-east of iran. extraction of genomic dna was based on the gu...