Genipin (GNP) effectively inhibits uncoupling protein 2 (UCP2), which regulates the leakage of protons across the inner mitochondrial membrane. UCP2 inhibition may induce pancreatic adenocarcinoma cell death by increasing reactive oxygen species (ROS) levels. In this study, the hydroxyls at positions C10 (10-OH) and C1 (1-OH) of GNP were hypothesized to be the active groups that cause these inh...

In urban rail transit network, the passenger transfer time depends on the train connection states in transfer stations, so the optimization of the connection relations of arrival and departure time among trains is significant to improve the level of transfer service. Here, with the psychology of waiting passengers taken into consideration, the cost function of transfer waiting times has been es...

Two types of graphene-nanoplatelets (GNP-M and GNP-C) were incorporated in PLA (poly(lactic acid)) by melt blending. Materials were biodegraded during 6 months and characterized by XRD, tensile tests, DMA and biocompatibility assays. For both fillers, low loadings (0.25 wt.%) improved mechanical properties and decreased their decay until 6 months biodegradation. PLA degradation decreased its to...

Vinyl chloride (VC) is a toxic groundwater pollutant associated with plastic manufacture and chlorinated solvent use. Aerobic bacteria that grow on VC as a carbon and energy source can evolve in the laboratory from bacteria that grow on ethene, but the genetic changes involved are unknown. We investigated VC adaptation in two variants (JS623-E and JS623-T) of the ethene-oxidizing Mycobacterium ...

Appropriate scheduling and sequencing of tasks on machines is one of the basic and significant problems that a shop or a factory manager encounters with it, this is why in recent decades extensive researches have been done on scheduling issues. A type of scheduling problems is just-in-time (JIT) scheduling and in this area, motivated by JIT manufacturing, this study investigates a mathematical ...

We have reviewed the available data on VM, the amount of genetic variation in phenotypic traits produced each generation by mutation. We use these data to make several qualitative tests of the mutation-selection balance hypothesis for the maintenance of genetic variance (MSB). To compare VM values, we use three dimensionless quantities: mutational heritability, VM/VE, the mutational coefficient...

In this paper we extend a popular non-cooperative network creation game (NCG) [11] to allow for disconnected equilibrium networks. There are n players, each is a vertex in a graph, and a strategy is a subset of players to build edges to. For each edge a player must pay a cost α, and the individual cost for a player represents a trade-off between edge costs and shortest path lengths to all other...

This paper is concerned with the variety of ABR switch mechanisms available for implementation with the current end system definition. The various switch mechanisms can be broadly classified in two categories depending on the type of feedback information provided to the end system. The feedback mechanism is either binary involving setting the EFCI bit in the data cell header or explicit rate in...

In Greece, the training system and education can be adapted to distance lifelong e-learning and the teachers, the society and the economy can be benefited via the introduction and training of in-service teachers in (a) the Video Conferencing (VC) technology and mode of distant training, granted that VC is put into a learning framework, and (b) Knowledge Management (KM) methodology, through lect...