نتایج جستجو برای: glutamate transporter

تعداد نتایج: 89373  

Journal: :The Journal of biological chemistry 1993
J Hartinger R Jahn

Glutamate, the major excitatory neurotransmitter of the mammalian central nervous system, is stored in synaptic vesicles and released by exocytosis upon depolarization of the presynaptic nerve terminal. Synaptic vesicles possess an active glutamate-specific transporter that is driven by an electrochemical proton gradient across the vesicle membrane and requires chloride for maximal activity. In...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Tsung-Tair Yang Su-Jane Wang

Pyridoxine (vitamin B(6)) protects neurons against neurotoxicity. An excessive release of glutamate is widely considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases. We investigated whether pyridoxine affected glutamate release in rat cerebral cortex nerve terminals (synaptosomes). Pyridoxine inhibited the release of glutamate that was evoked by exp...

Journal: :The Biochemical journal 2011
Myoung Sup Shim Jin Young Kim Kwang Hee Lee Hee Kyoung Jung Bradley A Carlson Xue-Ming Xu Dolph L Hatfield Byeong Jae Lee

l(2)01810 causes glutamine-dependent megamitochondrial formation when it is overexpressed in Drosophila cells. In the present study, we elucidated the function of l(2)01810 during megamitochondrial formation. The overexpression of l(2)01810 and the inhibition of glutamine synthesis showed that l(2)01810 is involved in the accumulation of glutamate. l(2)01810 was predicted to contain transmembra...

Journal: :Nature Structural & Molecular Biology 2013

Journal: :Biological and Pharmaceutical Bulletin 2006

Journal: :Proceedings of the National Academy of Sciences 2000

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید