نتایج جستجو برای: graft rejection
تعداد نتایج: 111749 فیلتر نتایج به سال:
BACKGROUND There may be an allograft-enhancing effect by the liver on the renal allograft in the setting of simultaneous combined liver-kidney transplantation (CLKT) from the same donor. This study was performed to investigate whether an existing liver allograft could protect a kidney allograft from immunologic injury due to histoincompatibility in liver transplant recipients who received seque...
BACKGROUND The most important limiting factor in kidney transplantation is the scarcity of donor organs. Consequently, there is an increased use worldwide of kidneys from older deceased donors. High donor age is a known risk factor for acute cellular rejection and premature graft failure, and the optimal immunosuppressive regimen in these circumstances remains to be established. METHODS We in...
BACKGROUND It remains disputed whether cardiac retransplantation should be performed. This study aimed to evaluate our long-term experiences on cardiac retransplantation in adults. PATIENTS AND METHODS Between March 1989 and December 2004, 2% (28/1290) of cardiac retransplantations were performed. RESULTS The reasons for cardiac retransplantation were cardiac allograft vasculopathy (n=13; 4...
PURPOSE To determine changes in the central endothelium and thickness of grafted corneas and the cumulative probability of developing glaucoma, of graft rejection, and of graft failure 15 years after penetrating keratoplasty. DESIGN Longitudinal cohort study of 500 consecutive penetrating keratoplasties by one surgeon. METHODS Regrafted eyes, fellow eyes of bilateral cases, and patients not...
SIGNIFICANT improvements in the results of renal transplantation in the 1980s were largely due to the development of cyclosporine (CyA) and the use of antilymphocyte agents for induction protocols and/or treatment of rejection. However, rejection refractory to treatment with corticosteroids and/or antilymphocyte agents has remained a major obstacle to long-term success and account for a signifi...
A serum proteomics platform enabling expression Profiling in transplantation-associated clinical subsets gives an opportunity to identify non-invasive biomarkers that can accurately predict transplant outcome. In this study, we attempted to identify candidate serum biomarkers that could predict kidney allograft rejection/injury, regardless of its etiological and therapeutic heterogeneity. Using...
Bone marrow transplantation from an HLA-identical sibling is increasingly used in the treatment of severe aplastic anemia. One major problem with this approach is graft rejection that occurs in 25%-60% of patients conditioned for transplantation with cyclophosphamide. At most transplant centers it has been difficult to accurately identify patients at high risk for graft rejection. We studied a ...
Kidney allograft rejection can occur in clinically stable patients, but long-term significance is unknown. We determined whether early recognition of subclinical rejection has long-term consequences for kidney allograft survival in an observational prospective cohort study of 1307 consecutive nonselected patients who underwent ABO-compatible, complement-dependent cytotoxicity-negative crossmatc...
Background: The chemokine CXCL10 is a potent chemoattractant for activated lymphocytes and dendritic cells and mediates vascular injury by inducing intimal hyperplasia and inhibition of endothelial cell growth. Neutralisation of CXCL10 prolongs allograft survival and transplant knock-out models have shown that this chemokine is required for the initiation and development of graft failure due to...
INTRODUCTION This study aimed to investigate the effectiveness of low-dose daclizumab for prevention of acute kidney allograft rejection and to evaluate differences between men and women receiving living donor transplants. MATERIALS AND METHODS This randomized controlled trial was performed on 120 living donor kidney transplant recipients. Participants in the case group received a low dose of...
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